Showing papers in "Journal of Lipid Research in 1992"

TL;DR: It is of particular interest, therefore, that all of the exchangeable apolipoproteins except apoA-II and C-I, contain amphipathic helixes of class G*.

TL;DR: Results indicated a consistent relationship between plasma TG levels and apoE phenotype among different populations and an ubiquitous relationship between normolipidemic and hyperlipidemic subjects.

TL;DR: Findings show that 7.7% of energy (mean, 24 g/day) of trans fatty acids in the diet significantly lowered HDL cholesterol and raised LDL cholesterol relative to linoleic acid.

TL;DR: In 27 mildly hypercholesterolemic men, total and LDL cholesterol were significantly lower during the 3-week oleic acid-rich diet, and were similar during the other three diets, which led to significant elevations in the level of Lp compared to all the other test diets.

TL;DR: The data suggest that neither of these cytokines is absolutely required for the increase in serum triglycerides induced by LPS, raising the possibility that other cytokines, small molecular mediators, or LPS itself may play a crucial role.

TL;DR: It is suggested that the recycling of vitamin E and other phenolic antioxidants by plasma reductants may be an important mechanism for the enhanced antioxidant protection of LDL.

TL;DR: The physiological significance of saposins is underlined by their accumulation in tissues of lysosomal storage disease patients and the occurrence of sphingolipidosis due to mutations in the prosaposin gene.

TL;DR: Examination of the effect of dietary fatty acid composition on serum Lp[a] levels in three strictly controlled experiments with healthy normocholesterolemic men and women found that saturated fatty acids are a strong risk factor for coronary heart disease.

TL;DR: The purpose of this review is to inspect and evaluate those instances where lipids and proteins interact in providing the epidermal barrier and to briefly review the macroscopic and microscopic anatomy of the skin, as well as the biochemistry of theEpidermal lipids.

TL;DR: The effect of dietary supplementation with alpha-tocopherol on the time course of copper-catalyzed oxidation of LDL was tested in a randomized placebo-controlled single-blind study and did not result in any side effects or exert an adverse effect on the plasma lipid and lipoprotein profile.

TL;DR: Structural modifications on YM 175 to enhance cell permeability may result in a new class of cholesterol-lowering agents.

TL;DR: The principles governing the in vitro solubility of the common natural conjugated and unconjugated bile acids and salts in relation to pH, micelle formation, and Ca2+ concentration are considered from a theoretical standpoint and then correlated first with experimental observations on model systems and second with the formation of precipitates containing bile acid in health and disease.

TL;DR: It is proposed that cholesterol efflux from cell membranes is influenced by three factors: the distribution of cholesterol between cholesterol-rich and cholesterol-poor membrane domains, the diffusion of cholesterol molecules through the extracellular unstirred water layer, and the transient interaction of segments of the amphipathic helix of the HDL apolipoprotein with cholesterol- poor membrane domains resulting in enhanced cholesterol effux.

TL;DR: The phylogenetic reconstruction suggests that ancestral PL diverged earlier than HL and LPL, which share a more recent root, and a conservation index (CI) is constructed to display conserved structural features within the lipase gene family, a CI of 1.0 signifying perfect conservation.

TL;DR: Three studies show that triacylglycerols containing saturated or polyunsaturated fatty acids have effects on the major processes that regulate the plasma LDL-cholesterol level that are qualitatively and quantitatively distinct.

TL;DR: A rapid and simple method for separation of serum lipid classes for fatty acid analysis with a single aminopropyl solid phase glass column is described, providing an efficient and convenient tool to follow fatty acid patterns in serum lipid fractions.

TL;DR: This review summarizes the development of, and recent studies in, the field of protein prenylation, with particular emphasis on the biochemistry of the processes involved.

TL;DR: These findings indicate that apoE may play two complementary roles in neurite outgrowth, when complexed with lipoproteins, which would be complementary in promoting target-directed nerve growth in vivo and provide the first direct evidence that apeE and apo E-containing lipoproteinins can modulate the outgrowth of neuronal processes.

TL;DR: The cholesterol 7a-hydroxylase is the only enzyme that is capable of regulating the overall conversion into bile acids, and this mechanism is the most important mechanism for steroid side-chain degradation in connection with bile acid biosynthesis, the 27-

TL;DR: During 2 weeks of alcohol withdrawal, plasma CETP concentration and activity of 8 subjects increased, whereas HDL cholesterol decreased by 42% (P less than 0.02), and this paper concludes that alcohol consumption is associated with increased HDL cholesterol concentration and reduced CETP activity.

TL;DR: It is shown that there is no discrimination between the three tocopherols during absorption and secretion in chylomicrons, but subsequently there is a preferential enrichment of very low density lipoprotein (VLDL) with RRR-alpha-tocopherol.

TL;DR: It is demonstrated that remnant- like chylomicrons and a population of remnant-like VLDL can be isolated and quantified in blood plasma obtained in the postabsorptive state from normotriglyceridemic and hypertriglyceridemia individuals alike.

TL;DR: The current knowledge of cholesterol transport mechanisms and pathways are outlined and approaches that may help define cholesterol trafficking mechanisms in molecular detail are described.

TL;DR: It is concluded that apoC- III is likely to exhibit a physiological role in regulating LPL activity since the derived dissociation constants for the LPL-apoC-III interaction are within the physiological concentration range of plasma apo C-III.

TL;DR: At different concentrations of HClO4, each method was successfully used to determine the phosphorus content in phosphatidylethanolamine and sphingomyelin standards that covered the proposed sensitivity ranges.

TL;DR: The results suggest that the fatty acid unsaturation of dietary oils is not the only determining factor of the antioxidant capacity of lipoproteins in this animal model, and the optimal balance between the content of unsaturated fatty acids and natural antioxidants in dietary oils appears to be of major importance.

TL;DR: Because protein conformation and charge are critical in metabolic regulation, the agarose gel electrophoresis technique provides a valuable analytical tool that should help to elucidate further details of the structure-function relationships of serum lipoprotein particles.

TL;DR: Results of this study indicate that inhibition of intracellular triglyceride synthesis decreases the secretion of VLDL-TG and apoB-100, and does not result in the release of a dense, triglyceride-depleted lipoprotein.

TL;DR: Cryopreservation of LDL in 10% sucrose (w/v) completely prevented the structural and functional changes incurred after short-term freezing, and LDL cryopreserved in sucrose for as long as 18 months displayed cell binding, uptake, and degradation very similar to that of freshly obtained LDL.