I
Ilya Frolov
Researcher at University of Alabama at Birmingham
Publications - 115
Citations - 8216
Ilya Frolov is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Alphavirus & Viral replication. The author has an hindex of 51, co-authored 112 publications receiving 7587 citations. Previous affiliations of Ilya Frolov include University of Washington & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
Sindbis virus expression vectors: packaging of RNA replicons by using defective helper RNAs.
TL;DR: A series of defective Sind Bis virus helper RNAs are described which can be used for packaging Sindbis virus RNA replicons and would be useful under conditions in which extensive amplification is advantageous.
Journal ArticleDOI
Alphavirus-based expression vectors : strategies and applications
Ilya Frolov,Thomas A. Hoffman,Béla M. Prágai,Sergey A. Dryga,Henry V. Huang,Sondra Schlesinger,Charles M. Rice +6 more
TL;DR: Alphaviruses are positive-strand RNA viruses that can mediate efficient cytoplasmic gene expression in insect and vertebrate cells that have been engineered for high-level expression of heterologous RNAs and proteins through recombinant DNA technology.
Journal ArticleDOI
The Old World and New World Alphaviruses Use Different Virus-Specific Proteins for Induction of Transcriptional Shutoff
Natalia Garmashova,Rodion Gorchakov,Eugenia Volkova,Slobodan Paessler,Elena I. Frolova,Ilya Frolov +5 more
TL;DR: These data provide new insights into alphavirus evolution and present a plausible explanation for the particular recombination events that led to the formation of western equine encephalitis virus (WEEV) from SINV- and EEEV-like ancestors.
Journal ArticleDOI
Noncytopathic Sindbis virus RNA vectors for heterologous gene expression
Eugene Agapov,Ilya Frolov,Brett D. Lindenbach,Béla M. Prágai,Sondra Schlesinger,Charles M. Rice +5 more
TL;DR: These vectors should prove to be flexible tools for the rapid expression of heterologous genes under conditions in which cellular metabolism is not perturbed, and they illustrate their utility with a number of foreign proteins.
Journal ArticleDOI
Roles of Nonstructural Protein nsP2 and Alpha/Beta Interferons in Determining the Outcome of Sindbis Virus Infection
TL;DR: It is demonstrated that a viral nonstructural protein, nsP2, is a significant regulator of Sindbis virus-host cell interactions and has implications for the development of improved alphavirus expression systems with better antigen-presenting potential.