D
Diane E. Griffin
Researcher at Johns Hopkins University
Publications - 410
Citations - 26436
Diane E. Griffin is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Virus & Sindbis virus. The author has an hindex of 88, co-authored 397 publications receiving 25137 citations. Previous affiliations of Diane E. Griffin include Global Virus Network & Johns Hopkins University School of Medicine.
Papers
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Journal ArticleDOI
Cytokine expression in the brain during the acquired immunodeficiency syndrome.
William R. Tyor,William R. Tyor,Jonathan D. Glass,John W. Griffin,P. Scott Becker,Justin C. McArthur,Lena Bezman,Diane E. Griffin +7 more
TL;DR: There is a relative state of “immune activation” in the brains of HIV‐positive compared to HIV‐negative individuals, and a potential role for the immune system in the pathogenesis of HIV encephalopathy is suggested.
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Modulation of cell death by Bcl-XL through caspase interaction.
Rollie J. Clem,Rollie J. Clem,Emily H. Cheng,Emily H. Cheng,Christopher L. Karp,David G. Kirsch,Kazuyoshi Ueno,Atsushi Takahashi,Atsushi Takahashi,Michael B. Kastan,Diane E. Griffin,William C. Earnshaw,William C. Earnshaw,Michael A. Veliuona,Michael A. Veliuona,J. Marie Hardwick +15 more
TL;DR: Findings indicate that the recognition/cleavage site of Bcl-XL may facilitate protection against cell death by acting at the level of caspase activation and that cleavage of BCl-XL during the execution phase of cell death converts B cl-XL from a protective to a lethal protein.
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Mechanism of suppression of cell-mediated immunity by measles virus
Christopher L. Karp,Maria Wysocka,Larry M. Wahl,Joseph M. Ahearn,Peter J. Cuomo,Barbara Sherry,Giorgio Trinchieri,Diane E. Griffin +7 more
TL;DR: Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression.
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Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene
TL;DR: In this article, the Sindbis virus (SV) infection induces programmed cell death in non-neuronal cells, and if so, whether virus-induced cell death can be blocked by transfection with bcl-2.
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Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia.
Steven Lodewyk Wesselingh,Christopher Power,Jonathan D. Glass,William R. Tyor,Justin C. McArthur,Joshua M. Farber,John W. Griffin,Diane E. Griffin +7 more
TL;DR: Levels of IL‐4 messenger RNA were decreased in dementia and the loss of this and other macrophage downregulatory factors in demented patients may contribute to the increased expression of tumor necrosis factor‐α.