Rafik Fayzulin

TL;DR: It is demonstrated that a viral nonstructural protein, nsP2, is a significant regulator of Sindbis virus-host cell interactions and has implications for the development of improved alphavirus expression systems with better antigen-presenting potential.

TL;DR: The findings suggest that the use of the SINV genome as a vector for expression of structural proteins derived from more pathogenic, encephalitic alphaviruses is a promising strategy forAlphavirus vaccine development.

TL;DR: It is demonstrated that RepliVAX WN can be safely propagated at high titer in BHK cells and vaccine-certified Vero cells engineered to stably express the C protein needed to trans-complement repliVAx WN growth.

TL;DR: These chimeric SIN/VEE viruses are safe and efficacious in adult mice and hamsters and are potentially useful as VEEV vaccines, and immunized animals provide a useful model for studying the mechanisms of the anti-VEEV neuroinflammatory response, leading to the reduction of viral titers in the CNS and survival of animals.

TL;DR: To investigate IFN gene induction by the very first cells infected during in vivo infection with the flavivirus West Nile virus, mice were infected with high-titer preparations of WNV virus-like particles, which initiate viral genome replication in cells but fail to spread.