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In-Chul Lee
Researcher at Korea Research Institute of Bioscience and Biotechnology
Publications - 63
Citations - 1344
In-Chul Lee is an academic researcher from Korea Research Institute of Bioscience and Biotechnology. The author has contributed to research in topics: Oxidative stress & Malondialdehyde. The author has an hindex of 19, co-authored 57 publications receiving 1038 citations. Previous affiliations of In-Chul Lee include Chonnam National University.
Papers
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Journal ArticleDOI
The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats.
In-Chul Lee,Sung-Hwan Kim,Hyung-Seon Baek,Changjong Moon,Seong-Soo Kang,Sung-Ho Kim,Yun-Bae Kim,In-Sik Shin,Jong-Choon Kim +8 more
TL;DR: DADS induces antioxidant defense mechanism by activating Nrf2 pathway and reduces inflammatory response by inhibiting NF-κB activation, demonstrating that DADS increases the expression of phase II/antioxidant enzymes and simultaneously decreases theexpression of inflammatory mediators in CCl4-induced liver injury.
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Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling
In-Sik Shin,Na-Rae Shin,Na-Rae Shin,Ji-Won Park,Ji-Won Park,Chan-Mi Jeon,Ju-Mi Hong,Ok-Kyoung Kwon,Joong Sun Kim,In-Chul Lee,Jong-Choon Kim,Sei-Ryang Oh,Kyung-Seop Ahn +12 more
TL;DR: Melatonin effectively inhibited the neutrophil airway inflammation induced by CS and LPS treatment, which was closely related to downregulation of Erk phosphorylation.
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Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles
In-Chul Lee,In-Chul Lee,Je-Won Ko,Sung-Hyeuk Park,Na-Rae Shin,In-Sik Shin,Changjong Moon,Je-Hein Kim,Hyoung-Chin Kim,Jong-Choon Kim +9 more
TL;DR: Overall, the in vivo repeated dose toxicity study of Cu NPs and Cu MPs demonstrated that large surface area and high solubility in physiological milieus could directly influence the toxicological responses and biodistribution of Cu particles when administered orally.
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Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling
Ji-Won Park,In-Chul Lee,Na-Rae Shin,Chan-Mi Jeon,Ok-Kyoung Kwon,Je-Won Ko,Jong-Choon Kim,Sei-Ryang Oh,In-Sik Shin,Kyung-Seop Ahn +9 more
TL;DR: It is concluded that CuONPs exposure has a potential toxicity in humans with respiratory disease, which was associated with the MAPK phosphorylation.
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Mechanism for the protective effect of diallyl disulfide against cyclophosphamide acute urotoxicity in rats.
Sung-Hwan Kim,In-Chul Lee,Hyung-Seon Baek,In-Sik Shin,Changjong Moon,Chun-Sik Bae,Sung-Ho Kim,Jong-Choon Kim,Hyoung-Chin Kim +8 more
TL;DR: Results indicate that DADS prevented CP-induced bladder toxicity, in part, by detoxifying acrolein, via the Nrf-2-antioxidant response element pathway.