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In Kap Ko
Researcher at Wake Forest Institute for Regenerative Medicine
Publications - 39
Citations - 3252
In Kap Ko is an academic researcher from Wake Forest Institute for Regenerative Medicine. The author has contributed to research in topics: Kidney & Transplantation. The author has an hindex of 16, co-authored 37 publications receiving 2491 citations. Previous affiliations of In Kap Ko include Wake Forest University.
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A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
TL;DR: An integrated tissue–organ printer (ITOP) that can fabricate stable, human-scale tissue constructs of any shape is presented and the incorporation of microchannels into the tissue constructs facilitates diffusion of nutrients to printed cells, thereby overcoming the diffusion limit of 100–200 μm for cell survival in engineered tissues.
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In situ tissue regeneration through host stem cell recruitment.
TL;DR: This approach relies on development of a target-specific biomaterial scaffolding system that can effectively control the host microenvironment and mobilize host stem/progenitor cells to target tissues.
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3D Bioprinted Human Skeletal Muscle Constructs for Muscle Function Restoration
Ji Hyun Kim,Young-Joon Seol,In Kap Ko,Hyun Wook Kang,Young Koo Lee,Young Koo Lee,James J. Yoo,James J. Yoo,Anthony Atala,Anthony Atala,Sang Jin Lee,Sang Jin Lee +11 more
TL;DR: 3D bioprinting strategy was applied to fabricate an implantable, bioengineered skeletal muscle tissue composed of human primary muscle progenitor cells (hMPCs) and showed a highly organized multi-layered muscle bundle made by viable, densely packed, and aligned myofiber-like structures.
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Bioengineered transplantable porcine livers with re-endothelialized vasculature
In Kap Ko,Li Peng,Andrea Peloso,Charesa Smith,Abritee Dhal,Daniel B. Deegan,Cindy Zimmerman,Cara Clouse,Weixin Zhao,Thomas Shupe,Shay Soker,James J. Yoo,Anthony Atala +12 more
TL;DR: It is demonstrated, for the first time, that vascularized bioengineered livers, of clinically relevant size, can be transplanted and maintained in vivo, and represents the first step towards generating engineered livers for transplantation to patients with end-stage liver failure.
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Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function.
TL;DR: The results suggest that the 3D bioprinted human neural-skeletal muscle constructs can be rapidly integrated with the host neural network, resulting in accelerated muscle function restoration.