C
Carlos Kengla
Researcher at Wake Forest Institute for Regenerative Medicine
Publications - 12
Citations - 2077
Carlos Kengla is an academic researcher from Wake Forest Institute for Regenerative Medicine. The author has contributed to research in topics: Medicine & Engineering. The author has an hindex of 6, co-authored 8 publications receiving 1572 citations. Previous affiliations of Carlos Kengla include Wake Forest Baptist Medical Center & Wake Forest University.
Papers
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Journal ArticleDOI
A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
TL;DR: An integrated tissue–organ printer (ITOP) that can fabricate stable, human-scale tissue constructs of any shape is presented and the incorporation of microchannels into the tissue constructs facilitates diffusion of nutrients to printed cells, thereby overcoming the diffusion limit of 100–200 μm for cell survival in engineered tissues.
Journal ArticleDOI
Physics of bioprinting
Ashkan Shafiee,Elham Ghadiri,Elham Ghadiri,Haripriya Ramesh,Carlos Kengla,Jareer Kassis,Paul Calvert,David F. Williams,Ali Khademhosseini,Roger J. Narayan,Gabor Forgacs,Anthony Atala +11 more
TL;DR: The physics that underpins the most commonly employed approaches, such as extrusion, laser-based, and inkjet bioprinting are reviewed and an overview of the relevant parameters, their inter-relationships, and the equations that govern the various printing processes are provided.
Journal ArticleDOI
Bioprinted trachea constructs with patient-matched design, mechanical and biological properties.
Dongxu Ke,Hualin Yi,Hualin Yi,Savannah Est-Witte,Sunil George,Carlos Kengla,Sang Jin Lee,Anthony Atala,Sean V. Murphy +8 more
TL;DR: This study is the first of its kind to fabricate bioprinted tracheal constructs with separate cartilage and smooth muscle regions using polycaprolactone and human mesenchymal stem cell-laden hydrogels and shows comparable elastic modulus and yield stress compared to native trachea.
Book ChapterDOI
Extrusion-Based Bioprinting: Current Standards and Relevancy for Human-Sized Tissue Fabrication.
TL;DR: This chapter aims to provide an overview of what has been achieved to date through the use of microextrusion bioprinters and what major challenges still impede progress, and current research that shows promise in mitigating these challenges in the near future.
Book ChapterDOI
Bioprinting Complex 3D Tissue and Organs
TL;DR: Advances in the development and application of various biomaterials, stem cell populations, and technical tools is allowing researchers, for the first time, to accurately reproduce the structure and function of the healthy tissues in vitro for future transplantation into patients with chronic kidney disease.