Synthetic methods for azaheterocyclic phosphonates and their biological activity.

6. C-Sulfur-Substituted Aziridines 2110 6.

Synthesis and reactivity of C-heteroatom-substituted aziridines.

Centro de Quı́mica-Fı́sica Molecular (CQFM) and Institute of Nanosciences and Nanotechnology (IN), Departamento de Engenharia Quı́mica e Biológica, Instituto Superior Técnico, 1049-001 Lisboa, Portugal, REQUIMTE, Departamento de Quı́mica, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal, and iMed.UL, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

More sustainable approaches for the synthesis of N-based heterocycles.

Fluorinated phosphonates: synthesis and biomedical application.

Commercially available magnesium perchlorate is reported as an extremely efficient catalyst for the synthesis of α-aminophosphonates. A three-component reaction (3-CR) of an amine, an aldehyde or a ketone, and a di-/trialkyl phosphite (Kabachnik−Fields reaction) took place in one pot under solvent-free conditions to afford the corresponding α-aminophosphonates in high yields and short times. The use of solvent retards the rate of the reaction and requires a much longer reaction time than that for neat conditions. The reactions involving an aldehyde, an aromatic amine without any electron-withdrawing substituent, and a phosphite are carried out at rt. The reactions involving cyclic ketones, aromatic amines with an electron-withdrawing substituent, and aryl alkyl ketone (e.g., acetophenone) require longer reaction times at rt or heating. Magnesium perchlorate was found to be superior to other metal perchlorates and metal triflates during the reaction of 4-methoxybenzaldehyde, 2,4-dinitroaniline, and dimethy...

An extremely efficient three-component reaction of aldehydes/ ketones, amines, and phosphites (Kabachnik-Fields Reaction) for the synthesis of α-aminophosphonates catalyzed by magnesium perchlorate

Synthesis of 5-methoxylated 3-pyrrolin-2-ones via the rearrangement of chlorinated pyrrolidin-2-ones

A straightforward multigram synthesis of γ-amino-α,β-unsaturated phosphonates is described via a substitution-elimination sequence of dibromopropylphosphonates with primary amines. Depending on the primary amine, a one or two step procedure was utilized.

https://www.arkat-usa.org/get-file/20020/

Synthesis of γ-amino-α,β-unsaturated phosphonates via a substitution-elimination sequence of dibromophosphonates

Unusual access to 5-methoxy or 5,5-dimethoxy-4-methyl-3-pyrrolin-2-ones from chlorinated 4-methyl-pyrrolidin-2-ones.

54th International Symposium on Crop Protection, Gent, Belgium, May 7th 2002, p. 163. L. Decombel, G. Smagghe, L. Tirry, I. Laureyn, C.V. Stevens, In Vitro effects of current Insecticides and Phosphonylated Heterocycles on Insect Cell Cultures of Lepidoptera

Inge Laureyn

Papers

Synthetic methods for azaheterocyclic phosphonates and their biological activity.

Synthesis of 5-methoxylated 3-pyrrolin-2-ones via the rearrangement of chlorinated pyrrolidin-2-ones

Synthesis of γ-amino-α,β-unsaturated phosphonates via a substitution-elimination sequence of dibromophosphonates

Unusual access to 5-methoxy or 5,5-dimethoxy-4-methyl-3-pyrrolin-2-ones from chlorinated 4-methyl-pyrrolidin-2-ones.

54th International Symposium on Crop Protection, Gent, Belgium, May 7th 2002, p. 163. L. Decombel, G. Smagghe, L. Tirry, I. Laureyn, C.V. Stevens, In Vitro effects of current Insecticides and Phosphonylated Heterocycles on Insect Cell Cultures of Lepidoptera