Journal ArticleDOI
Synthetic methods for azaheterocyclic phosphonates and their biological activity.
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This article is published in Chemical Reviews.The article was published on 2004-11-10. It has received 415 citations till now.read more
Citations
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Synthesis and reactivity of C-heteroatom-substituted aziridines.
TL;DR: 6. C-Sulfur-Substituted Aziridines 2110 6.6% 7.2% 8.4% 9.1% 10.0%
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More sustainable approaches for the synthesis of N-based heterocycles.
TL;DR: This research presents a novel and scalable approach to nanosciences called “Smart Nanotechnology” that combines “smart chip” technology with traditional “nanofiltration” techniques.
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Fluorinated phosphonates: synthesis and biomedical application.
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An extremely efficient three-component reaction of aldehydes/ ketones, amines, and phosphites (Kabachnik-Fields Reaction) for the synthesis of α-aminophosphonates catalyzed by magnesium perchlorate
TL;DR: The Mg(ClO4)2-catalyzed alpha-aminophosphonate synthesis in the present study perhaps represents a true three-component reaction as no intermediate formation of either an imine or alpha-hydroxy phosphonate was observed that indicated the simultaneous involvement of the carbonyl compound, the amine, and the phosphite in the transition state.
References
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Asymmetric 1,3-Dipolar Cycloaddition Reactions
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Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs
Hassan Jomaa,Jochen Wiesner,Silke Sanderbrand,Boran Altincicek,Claus Weidemeyer,Martin Hintz,Ivana Türbachova,Matthias Eberl,Johannes Zeidler,Hartmut K. Lichtenthaler,Dominique Soldati,Ewald Beck +11 more
TL;DR: A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria and the presence of two genes encoding the enzymes DOXP synthase and DOXP reductoisomerase suggests that isoprene biosynthesis in P. falcIParum depends on the DOXP pathway.
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Biological activity of aminophosphonic acids
Paweł Kafarski,Barbara Lejczak +1 more
TL;DR: Aminophosphonates are analogues of amino acids in which a carboxylic moiety is replaced by phosphonic acid or related groups that inhibit enzymes involved in amino acid metabolism and thus affect the physiological activity of the cell.
Journal ArticleDOI
Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV.
TL;DR: The role of DPP IV/CD26 within the immune system is a combination of its exopeptidase activity and its interactions with different molecules to serve as a co-stimulatory molecule to influence T cell activity and to modulate chemotaxis.
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