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Ingrid M.E. Frohn-Mulder
Researcher at Erasmus University Rotterdam
Publications - 39
Citations - 2819
Ingrid M.E. Frohn-Mulder is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Cardiomyopathy & Heart disease. The author has an hindex of 24, co-authored 39 publications receiving 2501 citations. Previous affiliations of Ingrid M.E. Frohn-Mulder include Boston Children's Hospital & Erasmus University Medical Center.
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Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
Ingrid M.B.H. van de Laar,Rogier A. Oldenburg,Gerard Pals,Jolien W. Roos-Hesselink,Bianca M. de Graaf,Judith M.A. Verhagen,Yvonne M. Hoedemaekers,Rob Willemsen,Lies-Anne Severijnen,Hanka Venselaar,Gert Vriend,Peter M. T. Pattynama,Margriet Collée,Danielle Majoor-Krakauer,Don Poldermans,Ingrid M.E. Frohn-Mulder,Dimitra Micha,Janneke Timmermans,Yvonne Hilhorst-Hofstee,Sita M A Bierma-Zeinstra,Patrick Willems,Johan M. Kros,Edwin H.G. Oei,Ben A. Oostra,Marja W. Wessels,Aida M. Bertoli-Avella +25 more
TL;DR: The TGF-β pathway is endorsed as the primary pharmacological target for the development of new treatments for aortic aneurysms and osteoarthritis.
Journal ArticleDOI
Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome
Ingrid M.B.H. van de Laar,Denise van der Linde,Edwin H.G. Oei,Pieter K. Bos,Johannes H.J.M. Bessems,Sita M A Bierma-Zeinstra,Belle L. van Meer,Gerard Pals,Rogier A. Oldenburg,Jos A. Bekkers,Adriaan Moelker,Bianca M. de Graaf,Gabor Matyas,Ingrid M.E. Frohn-Mulder,Janneke Timmermans,Yvonne Hilhorst-Hofstee,Jan Maarten Cobben,Hennie T. Brüggenwirth,Lut Van Laer,Bart Loeys,Julie De Backer,Paul Coucke,Harry C. Dietz,Patrick Willems,Ben A. Oostra,Anne De Paepe,Jolien W. Roos-Hesselink,Aida M. Bertoli-Avella,Marja W. Wessels +28 more
TL;DR: In the majority of patients, early-onset joint abnormalities, including osteoarthritis and osteochondritis dissecans, were the initial symptom for which medical advice was sought, and involved mainly aortic aneurysms and dissections.
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The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy.
Yvonne M. Hoedemaekers,Kadir Caliskan,Michelle Michels,Ingrid M.E. Frohn-Mulder,Jasper J. van der Smagt,Judith E. Phefferkorn,Marja W. Wessels,Folkert J. ten Cate,Eric J.G. Sijbrands,Dennis Dooijes,Danielle Majoor-Krakauer +10 more
TL;DR: LVNC is predominantly a genetic cardiomyopathy with variable presentation ranging from asymptomatic to severe, and requires genetic counseling, DNA diagnostics, and cardiological family screening.
Journal ArticleDOI
Efficacy of Routine Fetal Ultrasound Screening for Congenital Heart Disease in Normal Pregnancy
E. Buskens,Diederick E. Grobbee,Ingrid M.E. Frohn-Mulder,P. A. Stewart,R.E. Juttmann,Juriy W. Wladimiroff,John Hess +6 more
TL;DR: The results suggest that the current mode of routine prenatal ultrasound screening for congenital malformations is inefficient, particularly for cardiac anomalies.
Journal ArticleDOI
Familial Evaluation in Catecholaminergic Polymorphic Ventricular Tachycardia Disease Penetrance and Expression in Cardiac Ryanodine Receptor Mutation–Carrying Relatives
Christian van der Werf,Ineke Nederend,Nynke Hofman,Nan van Geloven,Corné Ebink,Ingrid M.E. Frohn-Mulder,A. Marco Alings,Hans A. Bosker,Frank A.L.E. Bracke,Freek van den Heuvel,Reinier A. Waalewijn,Hennie Bikker,J. Peter van Tintelen,Zahurul A. Bhuiyan,Zahurul A. Bhuiyan,Maarten P. van den Berg,Arthur A.M. Wilde +16 more
TL;DR: Relatives carrying an Ryr2 mutation show a marked phenotypic diversity and may be associated with severity of the phenotype, and the arrhythmic event rate during follow-up was low.