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Ingrid M.B.H. van de Laar
Researcher at Erasmus University Rotterdam
Publications - 61
Citations - 2777
Ingrid M.B.H. van de Laar is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Aneurysm & Aortic dissection. The author has an hindex of 21, co-authored 60 publications receiving 2205 citations. Previous affiliations of Ingrid M.B.H. van de Laar include Erasmus University Medical Center & Ghent University Hospital.
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Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
Ingrid M.B.H. van de Laar,Rogier A. Oldenburg,Gerard Pals,Jolien W. Roos-Hesselink,Bianca M. de Graaf,Judith M.A. Verhagen,Yvonne M. Hoedemaekers,Rob Willemsen,Lies-Anne Severijnen,Hanka Venselaar,Gert Vriend,Peter M. T. Pattynama,Margriet Collée,Danielle Majoor-Krakauer,Don Poldermans,Ingrid M.E. Frohn-Mulder,Dimitra Micha,Janneke Timmermans,Yvonne Hilhorst-Hofstee,Sita M A Bierma-Zeinstra,Patrick Willems,Johan M. Kros,Edwin H.G. Oei,Ben A. Oostra,Marja W. Wessels,Aida M. Bertoli-Avella +25 more
TL;DR: The TGF-β pathway is endorsed as the primary pharmacological target for the development of new treatments for aortic aneurysms and osteoarthritis.
Journal ArticleDOI
Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome
Ingrid M.B.H. van de Laar,Denise van der Linde,Edwin H.G. Oei,Pieter K. Bos,Johannes H.J.M. Bessems,Sita M A Bierma-Zeinstra,Belle L. van Meer,Gerard Pals,Rogier A. Oldenburg,Jos A. Bekkers,Adriaan Moelker,Bianca M. de Graaf,Gabor Matyas,Ingrid M.E. Frohn-Mulder,Janneke Timmermans,Yvonne Hilhorst-Hofstee,Jan Maarten Cobben,Hennie T. Brüggenwirth,Lut Van Laer,Bart Loeys,Julie De Backer,Paul Coucke,Harry C. Dietz,Patrick Willems,Ben A. Oostra,Anne De Paepe,Jolien W. Roos-Hesselink,Aida M. Bertoli-Avella,Marja W. Wessels +28 more
TL;DR: In the majority of patients, early-onset joint abnormalities, including osteoarthritis and osteochondritis dissecans, were the initial symptom for which medical advice was sought, and involved mainly aortic aneurysms and dissections.
Journal ArticleDOI
Mutations in a TGF-β ligand, TGFB3, cause syndromic aortic aneurysms and dissections.
Aida M. Bertoli-Avella,Elisabeth Gillis,Hiroko Morisaki,Judith M.A. Verhagen,Bianca M. de Graaf,Gerarda van de Beek,Elena M. Gallo,Boudewijn P.T. Kruithof,Hanka Venselaar,Loretha Myers,Steven Laga,Alexander J Doyle,Gretchen L. Oswald,Gert W. A. van Cappellen,Itaru Yamanaka,Robert van der Helm,Berna Beverloo,Annelies de Klein,Luba M. Pardo,Martin Lammens,Christina Evers,Koenraad Devriendt,Michiel Dumoulein,Janneke Timmermans,Hennie T. Brüggenwirth,Frans W. Verheijen,Inez Rodrigus,Gareth Baynam,Marlies Kempers,Johan Saenen,Emeline M. Van Craenenbroeck,Kenji Minatoya,Ritsu Matsukawa,Takuro Tsukube,Noriaki Kubo,Robert M.W. Hofstra,Marie J ose Goumans,Jos A. Bekkers,Jolien W. Roos-Hesselink,Ingrid M.B.H. van de Laar,Harry C. Dietz,Lut Van Laer,Takayuki Morisaki,Marja W. Wessels,Bart Loeys +44 more
TL;DR: In this article, aneurysms affecting the aorta are a common condition associated with high mortality as a result of aortic dissection or rupture, and investigations of the pathogenic mechanisms invo...
Journal ArticleDOI
Aggressive cardiovascular phenotype of aneurysms-osteoarthritis syndrome caused by pathogenic SMAD3 variants.
Denise van der Linde,Ingrid M.B.H. van de Laar,Aida M. Bertoli-Avella,Rogier A. Oldenburg,Jos A. Bekkers,Francesco U.S. Mattace-Raso,Anton H. van den Meiracker,Adriaan Moelker,Fop van Kooten,Ingrid M.E. Frohn-Mulder,Janneke Timmermans,Els Moltzer,Jan Maarten Cobben,Lut Van Laer,Bart Loeys,Julie De Backer,Paul Coucke,Anne De Paepe,Yvonne Hilhorst-Hofstee,Marja W. Wessels,Jolien W. Roos-Hesselink +20 more
TL;DR: The cardiovascular phenotype of the aneurysms-osteoarthritis syndrome is described and early elective repair of the ascending aorta should be considered, as it predisposes patients to aggressive and widespread cardiovascular disease and is associated with high mortality.
Journal ArticleDOI
Cardiac β-myosin heavy chain defects in two families with non-compaction cardiomyopathy : linking non-compaction to hypertrophic, restrictive, and dilated cardiomyopathies
Yvonne M. Hoedemaekers,Kadir Caliskan,Danielle Majoor-Krakauer,Ingrid M.B.H. van de Laar,Michelle Michels,Maarten Witsenburg,Folkert J. ten Cate,Maarten L. Simoons,Dennis Dooijes +8 more
TL;DR: The identification of mutations in the sarcomeric cardiac beta-myosin heavy chain gene (MYH7), known to be associated with hypertrophic cardiomyopathy, are described and it is suggested that the molecular classification ofCardiomyopathies includes an MYH7-associated spectrum of NCCM with HCM, RCM, and DCM.