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Inken G. Huttner
Researcher at Victor Chang Cardiac Research Institute
Publications - 28
Citations - 1000
Inken G. Huttner is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: Zebrafish & Titin. The author has an hindex of 15, co-authored 25 publications receiving 833 citations. Previous affiliations of Inken G. Huttner include University of Maryland Biotechnology Institute & University of California, Berkeley.
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Journal ArticleDOI
Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart
Garnet Bendig,Matthias Grimmler,Inken G. Huttner,Georgia Wessels,Tillman Dahme,Steffen Just,Nicole Trano,Hugo A. Katus,Mark C. Fishman,Wolfgang Rottbauer +9 more
TL;DR: Evidence is provided that the heart uses the Integrin-ILK-beta-parvin network to sense mechanical stretch and respond with increased expression of ANF and VEGF, the latter of which was recently shown to augment cardiac force by increasing the heart's calcium transients.
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Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae.
James B. Ames,Kristin B. Hendricks,Thomas Strahl,Inken G. Huttner,Nobuko Hamasaki,Jeremy Thorner +5 more
TL;DR: The FRQ1 gene is essential for growth of budding yeast and encodes a 190-residue, N-myristoylated (myr) calcium-binding protein, which resembles that of recoverin, and subcellular fractionation experiments showed that both the N- myristoyl group and Ca(2+)-binding contribute to the ability of Frq1 to associate with membranes.
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Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.
Bo Liang,Magdalena Soka,Alex Hørby Christensen,Morten S. Olesen,Anders Peter Larsen,Anders Peter Larsen,Filip K. Knop,Fan Wang,Jonas B. Nielsen,Martin N. Andersen,David T. Humphreys,Stefan A. Mann,Inken G. Huttner,Jamie I. Vandenberg,Jamie I. Vandenberg,Jesper Hastrup Svendsen,Stig Haunsø,Thomas Preiss,Guiscard Seebohm,Søren-Peter Olesen,Nicole Schmitt,Diane Fatkin,Diane Fatkin,Diane Fatkin +23 more
TL;DR: The findings demonstrate the functional importance of ITASK in the atrium and suggest that inactivation of TASK-1 may have diverse effects on atrial size and electrophysiological properties that can contribute to an arrhythmogenic substrate.
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Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models
Louis W. Wang,Louis W. Wang,Louis W. Wang,Inken G. Huttner,Inken G. Huttner,C. Santiago,C. Santiago,Scott H. Kesteven,Scott H. Kesteven,Ze-Yan Yu,Ze-Yan Yu,Michael P. Feneley,Michael P. Feneley,Michael P. Feneley,Diane Fatkin,Diane Fatkin,Diane Fatkin +16 more
TL;DR: It is demonstrated that high frequency echocardiography allows reliable in vivo cardiac assessment in adult zebrafish and makes recommendations for optimizing data acquisition and analysis.
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Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1).
Thomas Strahl,Inken G. Huttner,Jacqueline D. Lusin,Masanori Osawa,David S. King,Jeremy Thorner,James B. Ames +6 more
TL;DR: Frq1 may activate Pik1 by facilitating membrane targeting via the exposed N-myristoyl group and by imposing a structural transition that promotes association of the lipid kinase unique motif with the kinase domain.