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Insook Kim
Researcher at Leidos
Publications - 51
Citations - 2913
Insook Kim is an academic researcher from Leidos. The author has contributed to research in topics: Transactivation & Antibody. The author has an hindex of 27, co-authored 48 publications receiving 2624 citations. Previous affiliations of Insook Kim include National Institutes of Health & Science Applications International Corporation.
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Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Insook Kim,Sung-Hoon Ahn,Takeshi Inagaki,Mihwa Choi,Shinji Ito,Grace L. Guo,Grace L. Guo,Steven A. Kliewer,Frank J. Gonzalez +8 more
TL;DR: Evidence is provided that FXR-mediated repression of bile acid synthesis requires the complementary actions of FXR in both liver and intestine and mechanistic differences in feedback repression of CYP7A1 and CYP8B1 are revealed.
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Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
TL;DR: A potential role for FXR and BAs in hepatocarcinogenesis is revealed and increased cell proliferation is revealed as revealed by increased PCNA mRNA and BrdU incorporation.
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Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression
TL;DR: Pregnane X receptor expression was shown to be protective in inflammatory bowel disease (IBD), however, the mechanism by which PXR provides protection remains unclear.
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Nicotine Enhances Visuospatial Attention by Deactivating Areas of the Resting Brain Default Network
TL;DR: It is suggested that nicotine improved attentional performance by downregulating resting brain function in response to task-related cues, which suggests a nicotine-induced potentiation of the alerting properties of external stimuli.
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Hepatocyte nuclear factor 4α in the intestinal epithelial cells protects against inflammatory bowel disease
Sung-Hoon Ahn,Yatrik M. Shah,Junko Inoue,Keiichirou Morimura,Insook Kim,Sun Hee Yim,Gilles Lambert,Reiko Kurotani,Reiko Kurotani,Kunio Nagashima,Frank J. Gonzalez,Yusuke Inoue,Yusuke Inoue +12 more
TL;DR: While HNF4&agr; does not have a major role in normal function of the intestine, it protects the gut against DSS‐induced colitis and may play an important role in the increased susceptibility to acute colitis following an inflammatory insult.