G
Grace L. Guo
Researcher at University of Kansas
Publications - 64
Citations - 5859
Grace L. Guo is an academic researcher from University of Kansas. The author has contributed to research in topics: Farnesoid X receptor & Bile acid. The author has an hindex of 35, co-authored 49 publications receiving 5258 citations. Previous affiliations of Grace L. Guo include National Institutes of Health.
Papers
More filters
Journal ArticleDOI
International patterns and trends in thyroid cancer incidence, 1973–2002
Briseis A. Kilfoy,Briseis A. Kilfoy,Tongzhang Zheng,Theodore R. Holford,Xuesong Han,Mary H. Ward,Andreas Sjödin,Yaqun Zhang,Yana Bai,Yana Bai,Cairong Zhu,Cairong Zhu,Grace L. Guo,Nathaniel Rothman,Yawei Zhang +14 more
TL;DR: Analysis of published CI5 data suggests that thyroid cancer rates increased between 1973 and 2002 in most populations worldwide, and that the increase does not appear to be restricted to a particular region of the world or by the underlying rates of thyroid cancer.
Journal ArticleDOI
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Insook Kim,Sung-Hoon Ahn,Takeshi Inagaki,Mihwa Choi,Shinji Ito,Grace L. Guo,Grace L. Guo,Steven A. Kliewer,Frank J. Gonzalez +8 more
TL;DR: Evidence is provided that FXR-mediated repression of bile acid synthesis requires the complementary actions of FXR in both liver and intestine and mechanistic differences in feedback repression of CYP7A1 and CYP8B1 are revealed.
Journal ArticleDOI
The Farnesoid X-receptor Is an Essential Regulator of Cholesterol Homeostasis
Gilles Lambert,Marcelo Amar,Grace L. Guo,H. Bryan Brewer,Frank J. Gonzalez,Christopher J. Sinal +5 more
TL;DR: It is demonstrated that FXR is a critical regulator of normal cholesterol metabolism and that genetic changes affecting FXR function have the potential to be pro-atherogenic.
Journal ArticleDOI
Mechanism of tissue‐specific farnesoid X receptor in suppressing the expression of genes in bile‐acid synthesis in mice
TL;DR: The current study clearly elucidates the underlying molecular mechanism of hepatic versus intestinal Fxr in regulating the expression of genes critical for bile‐acid synthesis and hydrophobicity in the liver.
Journal ArticleDOI
Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway
Jonathan M. Maher,Matthew Z. Dieter,Lauren M. Aleksunes,Angela L. Slitt,Angela L. Slitt,Grace L. Guo,Yuji Tanaka,George L. Scheffer,Jefferson Y. Chan,José E. Manautou,Ying Chen,Timothy P. Dalton,Masayuki Yamamoto,Curtis D. Klaassen +13 more
TL;DR: The activation of the Nrf2 regulatory pathway stimulates the coordinated induction of hepatic Mrps in mice treated with oltipraz and butylated hydroxyanisole.