M
Marilyn A. Huestis
Researcher at National Institute on Drug Abuse
Publications - 402
Citations - 21351
Marilyn A. Huestis is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Cannabis & Poison control. The author has an hindex of 75, co-authored 374 publications receiving 19295 citations. Previous affiliations of Marilyn A. Huestis include University of Maryland, Baltimore & University at Buffalo.
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Journal ArticleDOI
Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid.
TL;DR: The results indicated that both ionization types showed matrix effect, but ESI was more susceptible than APCI, while SPE was necessary for extensive clean up of plasma prior to LC-APCI-MS/MS.
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Synthetic cannabinoids: Epidemiology, pharmacodynamics, and clinical implications
Marisol S. Castaneto,David A. Gorelick,Nathalie A. Desrosiers,Nathalie A. Desrosiers,Rebecca L. Hartman,Rebecca L. Hartman,Sandrine Pirard,Marilyn A. Huestis +7 more
TL;DR: A comprehensive review, based on a systematic electronic literature search, of SC epidemiology and pharmacology and their clinical implications is presented, showing in vitro and animal in vivo studies show SC pharmacological effects 2-100 times more potent than THC.
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Early-onset cannabis use and cognitive deficits: what is the nature of the association?
Harrison G. Pope,Amanda J. Gruber,James I. Hudson,Geoffrey H. Cohane,Marilyn A. Huestis,Deborah A. Yurgelun-Todd +5 more
TL;DR: Early-onset cannabis users exhibit poorer cognitive performance than late-ONSet users or control subjects, especially in VIQ, but the cause of this difference cannot be determined from the data.
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Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers
Jussi Hirvonen,Robert S. Goodwin,Cheng Ta Li,Garth E. Terry,Sami S. Zoghbi,Cheryl L. Morse,Victor W. Pike,Nora D. Volkow,Marilyn A. Huestis,Robert B. Innis +9 more
TL;DR: Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in human subjects who chronically smoke cannabis is shown, using positron emission tomography imaging, for the first direct demonstration of cortical cannabinoids CB1 receptor downregulation as a neuroadaptation that may promote cannabis dependence in human brain.
Journal ArticleDOI
Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana.
TL;DR: This study provides the first complete pharmacokinetic profile of the absorption of THC and appearance of metabolites during marijuana smoking, which has implications for understanding the mechanisms underlying the performance-impairing effects of marijuana, as well as for aiding forensic interpretation of cannabinoid blood levels.