Ioan Stefan Florian

TL;DR: The custom-made implants for cranioplasty showed a significant improvement in morphology and may be very useful for repairing large and complex-shaped cranial defects and for the bone reconstruction of other sites.

TL;DR: GSCs were highly sensitive to the combination of Met and Soraf which reduced cell proliferation, increased oxidative stress, inhibited efflux pump activity and ultimately killed GSCs.

TL;DR: The potential employment of metformin and arsenic trioxide (ATO) in glioblastoma therapy is discussed focusing on their effects on GSC.

TL;DR: The biomolecular characteristics of tumors, such as appropriate expression of organic cation transporters or genetic alterations including p53, K-ras, LKB1, and PI3K may impact metformin’s anticancer efficiency, could indicate a need for tumor genetic profiling in order to identify patients most likely to benefit from meetformin treatment.

TL;DR: The effects of combining metformin with the standard treatment-of-care is investigated, as this drug has shown surprising results in the treatment of breast cancer, being also associated with lower mortality in several other malignancies.