C
Ciprian Tomuleasa
Researcher at Iuliu Hațieganu University of Medicine and Pharmacy
Publications - 209
Citations - 3228
Ciprian Tomuleasa is an academic researcher from Iuliu Hațieganu University of Medicine and Pharmacy. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 28, co-authored 182 publications receiving 2532 citations. Previous affiliations of Ciprian Tomuleasa include Johns Hopkins University School of Medicine & Babeș-Bolyai University.
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Journal ArticleDOI
Exosomes as divine messengers: are they the Hermes of modern molecular oncology?
Cornelia Braicu,Ciprian Tomuleasa,Paloma Monroig,Andrei Cucuianu,Ioana Berindan-Neagoe,George A. Calin +5 more
TL;DR: The need of developing patient-targeted treatments by applying the conceptualization of exosomal-derived miRNA-based therapeutics is emphasized, as it makes them interesting tools in clinical diagnostics and ideal candidates for biomarkers.
Journal ArticleDOI
Human bile contains MicroRNA‐laden extracellular vesicles that can be used for cholangiocarcinoma diagnosis
Ling Li,David L. Masica,Masaharu Ishida,Ciprian Tomuleasa,Sho Umegaki,Anthony N. Kalloo,Christos S. Georgiades,Vikesh K. Singh,Mouen A. Khashab,Stuart K. Amateau,Zhiping Li,Patrick I. Okolo,Anne Marie Lennon,Payal Saxena,Jean-François Geschwind,Todd Schlachter,Kelvin Hong,Timothy M. Pawlik,Marcia I. Canto,Joanna Law,Reem Z. Sharaiha,Clifford R. Weiss,Paul J. Thuluvath,Michael Goggins,Eun Ji Shin,Haoran Peng,Vivek Kumbhari,Susan Hutfless,Liya Zhou,Esteban Mezey,Stephen J. Meltzer,Rachel Karchin,Florin M. Selaru +32 more
TL;DR: Findings establish the importance of using extracellular vesicles, rather than whole bile, for developing miR‐based disease markers in bile and develop a novel bile‐based CCA diagnostic panel that is stable, reproducible, and has potential clinical utility.
Journal ArticleDOI
The new era of nanotechnology, an alternative to change cancer treatment.
Ancuta Jurj,Cornelia Braicu,Laura-Ancuta Pop,Ciprian Tomuleasa,Claudia Gherman,Ioana Berindan-Neagoe +5 more
TL;DR: The background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, is highlighted, with a special emphasis on hematological malignancies.
Journal Article
Isolation and Characterization of Hepatic Cancer Cells with Stem-Like Properties from Hepatocellular Carcinoma
Ciprian Tomuleasa,Olga Soritau,Dan Rus-Ciuca,Teodora Pop,Daniela Todea,Ofelia Mosteanu,Bogdan Pintea,Vasile Foris,Sergiu Susman,Gabriel Kacso,Alexandru Irimie +10 more
TL;DR: The unique characteristics identified in cancer stem cells explain self-renewal and could drive metastasis in patients that have received treatment for cancer.
Journal Article
Gold nanoparticles conjugated with cisplatin/doxorubicin/capecitabine lower the chemoresistance of hepatocellular carcinoma-derived cancer cells.
Ciprian Tomuleasa,Olga Soritau,Anamaria Orza,Mircea Dudea,Bobe Petrushev,Ofelia Mosteanu,Sergiu Susman,Adrian Florea,Emoke Pall,Mihaela Aldea,Gabriel Kacso,Victor Cristea,Ioana Berindan-Neagoe,Alexandru Irimie +13 more
TL;DR: This approach could offer a new chemotherapy strategy for patients diagnosed with unresectable hepatocellular carcinoma (HCC) and proposes a novel platform therapy with minimal toxicity and increased efficacy profiles for the destruction of hepatic cancer cells.