A
Alexandru Irimie
Researcher at Iuliu Hațieganu University of Medicine and Pharmacy
Publications - 144
Citations - 3706
Alexandru Irimie is an academic researcher from Iuliu Hațieganu University of Medicine and Pharmacy. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 27, co-authored 136 publications receiving 2684 citations.
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Journal ArticleDOI
A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer.
Cornelia Braicu,Mihail Buse,Constantin Ioan Busuioc,Rares Drula,Diana Gulei,Lajos Raduly,Alexandru Rusu,Alexandru Irimie,Atanas G. Atanasov,Ondrej Slaby,Calin Ionescu,Ioana Berindan-Neagoe +11 more
TL;DR: New insights are discussed into MAPK as a complex cell signaling pathway with roles in the sustenance of cellular normal conduit, response to cancer therapy, and activation of compensatory pathways.
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Apoptosis in cancer: key molecular signaling pathways and therapy targets.
TL;DR: This review provides references concerning the apoptotic molecules, their interactions, the mechanisms involved in apoptosis resistance, and also the modulation of apoptosis for the treatment of cancer.
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CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations
Roxana S. Redis,Anieta M. Sieuwerts,Maxime P. Look,Oana Tudoran,Cristina Ivan,Riccardo Spizzo,Xinna Zhang,Vanja de Weerd,Masayoshi Shimizu,Hui Ling,Rares Buiga,Victor Ioan Pop,Alexandru Irimie,Riccardo Fodde,Isabella Bedrosian,John W.M. Martens,John A. Foekens,Ioana Berindan-Neagoe,Ioana Berindan-Neagoe,George A. Calin +19 more
TL;DR: In this paper, the authors determined the prognostic value of CCAT2, a novel long ncRNA recently characterized by their group and overlapping SNP rs6983267, in BC patients.
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The Role of Nrf2 Activity in Cancer Development and Progression.
Alina-Andreea Zimta,Diana Cenariu,Alexandru Irimie,Lorand Magdo,Seyed Mohammad Nabavi,Atanas G. Atanasov,Ioana Berindan-Neagoe +6 more
TL;DR: Nrf2’s role in cancer prevention, diagnosis, prognosis, and therapy is still in its infancy, and the future strategic planning of Nrf2-based oncological approaches should also consider the complex interaction between NRF2 and its various activators and inhibitors.
Journal ArticleDOI
The relationship between the structure and biological actions of green tea catechins.
Cornelia Braicu,Michael Ladomery,Veronica Sanda Chedea,Alexandru Irimie,Ioana Berindan-Neagoe +4 more
TL;DR: This review summarises the benefit catechins to human health, the main molecular pathways modulated by catech Ins, and the relationship between the structure and activity of the catechin needs to be studied further.