I
Irène Brigger
Researcher at University of Paris-Sud
Publications - 8
Citations - 4052
Irène Brigger is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: Drug carrier & Drug delivery. The author has an hindex of 8, co-authored 8 publications receiving 3865 citations. Previous affiliations of Irène Brigger include Centre national de la recherche scientifique & University of Paris.
Papers
More filters
Journal ArticleDOI
Nanoparticles in cancer therapy and diagnosis
TL;DR: The in vivo fate of these systems, after intravascular or tumoral administration, is discussed, as well as the mechanism involved in tumor regression, and the application of nanoparticles in imaging for cancer diagnosis is focused on.
Journal ArticleDOI
Drug delivery to resistant tumors: the potential of poly(alkyl cyanoacrylate) nanoparticles
TL;DR: The purpose of this paper is to summarize the results of the use of poly(alkyl cyanoacrylate) nanoparticles to overcome multidrug resistance (MDR) phenomena at both the cellular and the non-cellular level.
Journal ArticleDOI
Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting.
Irène Brigger,Jackie Morizet,Geneviève Aubert,Hélène Chacun,Marie-José Terrier-Lacombe,Patrick Couvreur,Gilles Vassal +6 more
TL;DR: The aim of the present study was to evaluate the tumor accumulation of radiolabeled long-circulating poly(ethylene glycol) (PEG)-coated hexadecylcyanoacrylate nanospheres and non-PEG-coated Hexade cylinders (used as control), after intravenous injection in Fischer rats bearing intracerebrally well established 9L gliosarcoma.
Journal ArticleDOI
PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases
Pilar Calvo,Bruno Gouritin,Irène Brigger,Corinne Ida Lasmézas,Jean-Philippe Deslys,Alun Williams,Jean P. Andreux,Dominique Dormont,Patrick Couvreur +8 more
TL;DR: PEGylated polymeric nanoparticles are presented as a potential efficient drug carrier for the delivery of active therapeutic molecules in prion experimental diseases and showed a higher uptake by the spleen and the brain which are both the target tissues of PrPres accumulation in scrapie infected animals.
Journal ArticleDOI
Negative preclinical results with stealth nanospheres-encapsulated Doxorubicin in an orthotopic murine brain tumor model.
Irène Brigger,Jackie Morizet,Lysiane Laudani,Geneviève Aubert,Martine Appel,Valérie Velasco,Marie-Josée Terrier-Lacombe,Didier Desmaële,Jean d'Angelo,Patrick Couvreur,Gilles Vassal +10 more
TL;DR: Evaluation of the pre-clinical efficacy of PEG-coated poly(hexadecylcyanoacrylate) nanospheres when loaded with Doxorubicin, an anticancer drug which poorly distributes in the CNS revealed aggregation with plasma proteins as a consequence of the positive surface charge of these loaded particles, mainly responsible for 9L treatment failure.