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Irene Jiménez-Munguía
Researcher at National University of Science and Technology
Publications - 31
Citations - 667
Irene Jiménez-Munguía is an academic researcher from National University of Science and Technology. The author has contributed to research in topics: Lipid bilayer fusion & Streptococcus pneumoniae. The author has an hindex of 12, co-authored 30 publications receiving 519 citations. Previous affiliations of Irene Jiménez-Munguía include University of Córdoba (Spain) & University of Veterinary Medicine Vienna.
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Characterization of protective extracellular membrane-derived vesicles produced by Streptococcus pneumoniae
Alfonso Olaya-Abril,Rafael Prados-Rosales,Michael J. McConnell,Reyes Martín-Peña,José A. González-Reyes,Irene Jiménez-Munguía,Lidia Gómez-Gascón,Javier Burón Fernández,Jose L. Luque-Garcia,Carlos García-Lidón,Hector Estevez,Jerónimo Pachón,Ignacio Obando,Arturo Casadevall,Liise Anne Pirofski,Manuel J. Rodríguez-Ortega,Manuel J. Rodríguez-Ortega +16 more
TL;DR: This work demonstrates the active production of vesicle production by Streptococcus pneumoniae from the plasma membrane, rather than being a product from cell lysis, and shows that pneumococcus produces membrane-derived vesicles particularly enriched in lipoproteins and short-chain fatty acids.
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Surfomics: shaving live organisms for a fast proteomic identification of surface proteins.
TL;DR: A novel second-generation approach has been developed, consisting of the digestion of live, intact cells with proteases, so that surface-exposed moieties (i.e. the "surfome" of a cell) are "shaved" and analyzed by LC/MS/MS.
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Another turn of the screw in shaving Gram-positive bacteria: Optimization of proteomics surface protein identification in Streptococcus pneumoniae.
Alfonso Olaya-Abril,Lidia Gómez-Gascón,Irene Jiménez-Munguía,Ignacio Obando,Manuel J. Rodríguez-Ortega +4 more
TL;DR: This work carried out the optimization of the "shaving" strategy for the Gram-positive human pathogen Streptococcus pneumoniae, a bacterium highly susceptible to autolysis, and set up the conditions for maximizing the identification of surface proteins containing sorting or exporting signals, and for minimizing cytoplasmic contamination.
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Exploring the pan-surfome of Streptococcus suis: Looking for common protein antigens
Lidia Gómez-Gascón,Inmaculada Luque,Alfonso Olaya-Abril,Irene Jiménez-Munguía,Ricardo A. Orbegozo-Medina,Esther Peralbo,Carmen Tarradas,Manuel J. Rodríguez-Ortega +7 more
TL;DR: The cell-wall protein SsnA appears to be the best candidate from this list, as it was that with the widest distribution among the analyzed pathogen types, it showed to be highly immunogenic and highly accessible to antibodies, as demonstrated by flow cytometry.
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Identification of potential new protein vaccine candidates through pan-surfomic analysis of pneumococcal clinical isolates from adults.
Alfonso Olaya-Abril,Irene Jiménez-Munguía,Lidia Gómez-Gascón,Ignacio Obando,Manuel J. Rodríguez-Ortega +4 more
TL;DR: The pan-surfomic approach shows its utility in the discovery of new proteins that can elicit protection against infectious microorganisms in humans by inducing the production of IgM antibodies in infected patients, thus indicating that they could enter the pipeline for vaccine studies.