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Irina Abakumova
Researcher at University of Zurich
Publications - 5
Citations - 431
Irina Abakumova is an academic researcher from University of Zurich. The author has contributed to research in topics: Microglia & Insulin receptor. The author has an hindex of 5, co-authored 5 publications receiving 364 citations.
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Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice
Annika Keller,Annika Keller,Annika Keller,Ana Westenberger,María Jesús Sobrido,María García-Murias,Aloysius Domingo,Renee L. Sears,R. R. Lemos,Andrés Ordóñez-Ugalde,Gaël Nicolas,José Eriton Gomes da Cunha,Elisabeth J. Rushing,Michael Hugelshofer,Moritz C. Wurnig,Andres Kaech,Regina Reimann,Katja Lohmann,Valerija Dobricic,Angel Carracedo,Igor Petrović,Janis M. Miyasaki,Irina Abakumova,Maarja Mäe,Maarja Mäe,Elisabeth Raschperger,Elisabeth Raschperger,Mayana Zatz,Katja Zschiedrich,Jörg Klepper,Elizabeth Spiteri,Elizabeth Spiteri,J.M. Prieto,I. Navas,Michael Preuss,Carmen Dering,Milena Jankovic,Martin Paucar,Per Svenningsson,Kioomars Saliminejad,Hamid Reza Khorram Khorshid,Ivana Novakovic,Adriano Aguzzi,Andreas Boss,Isabelle Le Ber,Gilles Defer,Didier Hannequin,Vladimir S. Kostic,Dominique Campion,Daniel H. Geschwind,Giovanni Coppola,Christer Betsholtz,Christer Betsholtz,Christine Klein,João Ricardo Mendes de Oliveira +54 more
TL;DR: The data present a clear link between Pdgfb mutations and brain calcifications in mice, as well as between PDGFB mutations and IBGC in humans.
Journal ArticleDOI
A neuroprotective role for microglia in prion diseases
Caihong Zhu,Uli S. Herrmann,Jeppe Falsig,Irina Abakumova,Mario Nuvolone,Petra Schwarz,Katrin Frauenknecht,Elisabeth J. Rushing,Adriano Aguzzi +8 more
TL;DR: Evidence is provided for a general protective role of microglia in the pathogenesis of prion diseases and its role in neurodegenerative disorders.
Journal ArticleDOI
Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains.
Caihong Zhu,Uli S. Herrmann,Bei Li,Irina Abakumova,Rita Moos,Petra Schwarz,Elisabeth J. Rushing,Marco Colonna,Adriano Aguzzi +8 more
TL;DR: It is concluded that TREM2 is involved in prion-induced microglial activation but does not noticeably modulate the pathogenesis of experimental prion infections.
Journal ArticleDOI
Unaltered Prion Pathogenesis in a Mouse Model of High-Fat Diet-Induced Insulin Resistance.
TL;DR: This study demonstrates that in a mouse model, insulin resistance does not significantly contribute to prion pathogenesis, and inoculated the insulin-resistant mice with prions.
Journal ArticleDOI
Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.
Annika Keller,Mario Nuvolone,Mario Nuvolone,Irina Abakumova,Andra Chincisan,Regina Reimann,Merve Avar,Daniel Heinzer,Simone Hornemann,Josephin Wagner,Daniel Kirschenbaum,Fabian F. Voigt,Caihong Zhu,Luca Regli,Fritjof Helmchen,Adriano Aguzzi +15 more
TL;DR: It is found that Pdgfbret/ret mice have a similar prion disease incubation time as their littermate controls regardless of the route of prion transmission, indicating that BBB permeability is irrelevant to the initiation of prions disease, even when prions are administered parenterally.