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Elisabeth Raschperger
Researcher at Karolinska Institutet
Publications - 21
Citations - 3831
Elisabeth Raschperger is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Mural cell & Tight junction. The author has an hindex of 17, co-authored 20 publications receiving 2733 citations. Previous affiliations of Elisabeth Raschperger include Ludwig Institute for Cancer Research & University of Gothenburg.
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Journal ArticleDOI
A molecular atlas of cell types and zonation in the brain vasculature
Michael Vanlandewijck,Michael Vanlandewijck,Liqun He,Maarj A. Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +20 more
TL;DR: The transcriptional basis of the gradual phenotypic change along the arteriovenous axis is uncovered and unexpected cell type differences are revealed: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells.
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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
Neil C. Henderson,Thomas D. Arnold,Yoshio Katamura,Marilyn M. Giacomini,Juan D Rodriguez,Joseph H. McCarty,Antonella Pellicoro,Elisabeth Raschperger,Elisabeth Raschperger,Christer Betsholtz,Christer Betsholtz,Peter G. Ruminski,David W. Griggs,Michael J. Prinsen,Jacquelyn J. Maher,John P. Iredale,Adam Lacy-Hulbert,Ralf H. Adams,Dean Sheppard +18 more
TL;DR: Pdgfrb-Cre effectively targeted myofibroblasts in multiple organs, and depletion of the αv integrin subunit using this system was protective in other models of organ fibrosis, including pulmonary and renal fibrosis.
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The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
Konstantin Gaengel,Colin Niaudet,Kazuhiro Hagikura,Bàrbara Laviña,Lars Muhl,Jennifer J. Hofmann,Lwaki Ebarasi,Staffan Nyström,Simin Rymo,Simin Rymo,Long Long Chen,Mei-Fong Pang,Yi Jin,Elisabeth Raschperger,Pernilla Roswall,Dörte Schulte,Rui Benedito,Jimmy Larsson,Mats Hellström,Jonas Fuxe,Per Uhlén,Ralf H. Adams,Lars Jakobsson,Arindam Majumdar,Dietmar Vestweber,Anne Uv,Christer Betsholtz +26 more
TL;DR: It is shown that S1PR1, a receptor for the blood-borne bioactive lipid sphingosine-1-phosphate (S1P), is critical for inhibition of angiogenesis and acquisition of vascular stability, and suggested that it acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses.
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Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.
Liqun He,Michael Vanlandewijck,Michael Vanlandewijck,Maarja Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Åsa Segerstolpe,Jianping Liu,Sonja Gustafsson,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +23 more
TL;DR: The dataset constitutes a comprehensive molecular atlas of vascular and vessel-associated cell types in the mouse brain and lung, and as such provides a strong foundation for future studies of vascular development and diseases.
Journal ArticleDOI
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination.
Lars Muhl,Guillem Genové,Stefanos Leptidis,Jianping Liu,Liqun He,Liqun He,Giuseppe Mocci,Ying Sun,Sonja Gustafsson,Byambajav Buyandelger,Indira V. Chivukula,Åsa Segerstolpe,Åsa Segerstolpe,Elisabeth Raschperger,Emil M. Hansson,Johan Björkegren,Johan Björkegren,Xiao-Rong Peng,Michael Vanlandewijck,Michael Vanlandewijck,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +22 more
TL;DR: Using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.