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Irina G. Makarenko
Researcher at Russian Academy of Sciences
Publications - 18
Citations - 1303
Irina G. Makarenko is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Hypothalamus & Magnocellular cell. The author has an hindex of 13, co-authored 18 publications receiving 1220 citations. Previous affiliations of Irina G. Makarenko include Heidelberg University & University of Münster.
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Journal ArticleDOI
Passive Stiffness Changes Caused by Upregulation of Compliant Titin Isoforms in Human Dilated Cardiomyopathy Hearts
Irina G. Makarenko,Christiane A. Opitz,Mark C. Leake,Ciprian Neagoe,Matthew H. Kulke,Judith K. Gwathmey,F. Del Monte,Roger J. Hajjar,Wolfgang A. Linke +8 more
TL;DR: It is concluded that a lower-than-normal proportion of Titin-based stiffness in end-stage failing hearts results partly from loss of titin and increased fibrosis, partly from titin-isoform shift.
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Isoform Diversity of Giant Proteins in Relation to Passive and Active Contractile Properties of Rabbit Skeletal Muscles
Lucas G. Prado,Irina G. Makarenko,Christian Andresen,Martina Krüger,Christiane A. Opitz,Wolfgang A. Linke +5 more
TL;DR: A low correlation exists between the active and passive mechanical properties of skeletal muscle fibers and titin, which contributes substantially to total passive stiffness, but this contribution varies greatly among muscles.
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Developmentally Regulated Switching of Titin Size Alters Myofibrillar Stiffness in the Perinatal Heart
TL;DR: Whereas the titin-isoform shift by 700 kDa ensures high passive stiffness of the postnatal cardiac myofibrils, the expression of specific fetal/neonatal cardiactitin isoforms may also have important functions for contractile properties, my ofibril assembly or turnover, and myocardial signaling during perinatal heart development.
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Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness.
TL;DR: It is shown how low-porosity polyacrylamide-gel electrophoresis, optimised for resolving megadalton proteins, can identify differences in titin-isoform expression in the hearts of 10 different vertebrate species and in several skeletal muscles of the rabbit.
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Distribution of serotonin 5-hydroxytriptamine 1B (5-HT1B) receptors in the normal rat hypothalamus
TL;DR: Immunofluorescent double-labeling revealed a great overlapping of the distribution 5-HT(1B) neurons and dense network of neuropeptide Y-immunoreactive fibers in paraventricular, supraoptic and arcuate nuclei.