A
Alexander Dityatev
Researcher at German Center for Neurodegenerative Diseases
Publications - 193
Citations - 11657
Alexander Dityatev is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Synaptic plasticity & Long-term potentiation. The author has an hindex of 57, co-authored 176 publications receiving 10303 citations. Previous affiliations of Alexander Dityatev include Otto-von-Guericke University Magdeburg & University of Bern.
Papers
More filters
Journal ArticleDOI
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
Massimiliano Caiazzo,Maria Teresa Dell’Anno,Elena Dvoretskova,Dejan Lazarevic,Dejan Lazarevic,Stefano Taverna,Damiana Leo,Tatyana D. Sotnikova,Andrea Menegon,Paola Roncaglia,Giorgia Colciago,Giovanni Russo,Piero Carninci,Gianni Pezzoli,Raul R. Gainetdinov,Stefano Gustincich,Stefano Gustincich,Alexander Dityatev,Vania Broccoli +18 more
TL;DR: A minimal set of three transcription factors were able to elicit dopaminergic neuronal conversion in prenatal and adult fibroblasts from healthy donors and Parkinson’s disease patients and might have significant implications for understanding critical processes for neuronal development, in vitro disease modelling and cell replacement therapies.
Journal ArticleDOI
Extracellular matrix molecules and synaptic plasticity
TL;DR: It is hypothesized that ECM molecules derived from neurons and glia might also shape synaptic plasticity through regulation of organelle trafficking, and by imposing diffusion constraints for neurotransmitters and trophic factors.
Journal ArticleDOI
The dual role of the extracellular matrix in synaptic plasticity and homeostasis
TL;DR: The ECM has a dual role as a promoter of structural and functional plasticity and as a degradable stabilizer of neural microcircuits, likely to be important for mental health.
Journal ArticleDOI
Mice Deficient in the Polysialyltransferase ST8SiaIV/PST-1 Allow Discrimination of the Roles of Neural Cell Adhesion Molecule Protein and Polysialic Acid in Neural Development and Synaptic Plasticity
Matthias Eckhardt,Olena Bukalo,Geneviève Chazal,Lihua Wang,Christo Goridis,Melitta Schachner,Rita Gerardy-Schahn,Harold Cremer,Alexander Dityatev +8 more
TL;DR: An essential role for ST8SiaIV in synaptic plasticity in hippocampal CA1 synapses is demonstrated, whereas PSA produced by different polysialyltransferase or polysIALyltransferases at early stages of differentiation regulates migration of neural precursor cells and correct lamination of mossy fibers.
Journal ArticleDOI
Activity-dependent formation and functions of chondroitin sulfate-rich extracellular matrix of perineuronal nets
Alexander Dityatev,Gert Brückner,Galina Dityateva,Jens Grosche,Ralf Kleene,Melitta Schachner +5 more
TL;DR: It is suggested that Ca2+ influx via AMPA receptors and L‐type channels is necessary for activity‐dependent formation of PNs, and removal of PN did not affect the number and distribution of perisomatic GABAergic contacts but increased the excitability of interneurons in cultures, implicating the extracellular matrix of PNS in regulation ofinterneuronal activity.