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Irina Rozovsky
Researcher at University of Southern California
Publications - 39
Citations - 7105
Irina Rozovsky is an academic researcher from University of Southern California. The author has contributed to research in topics: Glial fibrillary acidic protein & Astrocyte. The author has an hindex of 29, co-authored 39 publications receiving 6845 citations.
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Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
Mary P. Lambert,A. K. Barlow,Brett A. Chromy,C. Edwards,R. Freed,M. Liosatos,Todd E. Morgan,Irina Rozovsky,Barbara L. Trommer,Kirsten L. Viola,Pat Wals,Chuan Zhang,Caleb E. Finch,Grant A. Krafft,William L. Klein +14 more
TL;DR: It is hypothesized that impaired synaptic plasticity and associated memory dysfunction during early stage Alzheimer's disease and severe cellular degeneration and dementia during end stage could be caused by the biphasic impact of Abeta-derived diffusible ligands acting upon particular neural signal transduction pathways.
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Clusterin (apoJ) alters the aggregation of amyloid β-peptide (Aβ1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress
Tomiichiro Oda,Pat Wals,Heinz H. Osterburg,Steven A. Johnson,Giulio Maria Pasinetti,Todd E. Morgan,Irina Rozovsky,Stine Wb,Seth W. Snyder,Thomas F. Holzman +9 more
TL;DR: This novel activity of slowly sedimenting Aβ may enhance the neurotoxicity of Aβ deposits in AD brains, because soluble complexes have a potential for diffusing to damage distal neurons.
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Increased synaptic sprouting in response to estrogen via an apolipoprotein E-dependent mechanism: implications for Alzheimer's disease.
TL;DR: A mechanism for the protective effects of estrogens on AD is suggested and a link between two important risk factors in the etiology of AD, the apoE ε4 genotype and an estrogen-deficient state is provided.
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Age-related activation of microglia and astrocytes : In vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation
TL;DR: Both microglia and astrocytes originated from aging cerebral cortex maintain in vitro at least some of the activated phenotypes of aging glia that are observed in vivo, which may allow efficient analysis of glial age changes.
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Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro.
David J. Stone,Irina Rozovsky,Todd E. Morgan,Christopher P. Anderson,Hagop Hajian,Caleb E. Finch +5 more
TL;DR: In situ hybridization in combination with cell-specific markers showed that E2 increased apoE mRNA levels in both astrocytes and microglia, suggesting that heterotypic cellular interactions are important in the brain response to estrogens.