Chuan Zhang

TL;DR: It is hypothesized that impaired synaptic plasticity and associated memory dysfunction during early stage Alzheimer's disease and severe cellular degeneration and dementia during end stage could be caused by the biphasic impact of Abeta-derived diffusible ligands acting upon particular neural signal transduction pathways.

TL;DR: This work designs basic DNA building units in such a way that many copies of identical units assemble into larger three-dimensional structures, and tests this hierarchical self-assembly concept with DNA molecules that form three-point-star motifs, or tiles.

TL;DR: By coating nanoparticles protected with aliphatic ligands with an azide-bearing amphiphilic polymer, followed by the coupling of DNA to the polymer using strain-promoted azide -alkyne cycloaddition, nanoparticles bearing a high-density shell of nucleic acids can be created regardless of nanoparticle composition.

TL;DR: The results demonstrate that conformational flexibility could be explored to generate complex DNA nanostructures and might be further extended to other biomacromolecular systems, such as RNA and proteins.

TL;DR: A nano-composite capable of generating oxygen under near-infrared light for improved photodynamic and chemotherapy for treating cancer and to overcome the hypoxia-triggered PDT resistance.