S
Steven A. Johnson
Researcher at University of Southern California
Publications - 31
Citations - 4018
Steven A. Johnson is an academic researcher from University of Southern California. The author has contributed to research in topics: In situ hybridization & Hippocampal formation. The author has an hindex of 27, co-authored 31 publications receiving 3873 citations.
Papers
More filters
Journal ArticleDOI
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Heidi S. Phillips,Jeanne M. Hains,Mark Armanini,Gary R. Laramee,Steven A. Johnson,John W. Winslow +5 more
TL;DR: The possibility that decreased expression of BDNF may contribute to the progression of cell death in AD is suggested.
Journal ArticleDOI
GFAP mRNA increases with age in rat and human brain
TL;DR: The data indicate that increased GFAP protein or GFAP-immunoreactive astrocytes in rats and humans may result from transcriptional or post-transcriptional regulation and extend the number to three species showing an increase in GFAP mRNA with age.
Journal ArticleDOI
Clusterin (apoJ) alters the aggregation of amyloid β-peptide (Aβ1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress
Tomiichiro Oda,Pat Wals,Heinz H. Osterburg,Steven A. Johnson,Giulio Maria Pasinetti,Todd E. Morgan,Irina Rozovsky,Stine Wb,Seth W. Snyder,Thomas F. Holzman +9 more
TL;DR: This novel activity of slowly sedimenting Aβ may enhance the neurotoxicity of Aβ deposits in AD brains, because soluble complexes have a potential for diffusing to damage distal neurons.
Journal ArticleDOI
Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat
Patrick C. May,Martha Lampert-Etchells,Steven A. Johnson,Judes Poirier,Jeffrey N. Masters,Caleb E. Finch +5 more
TL;DR: Increased expression of pADHC-9 in Alzheimer's disease hippocampus may be a compensatory response mounted to retard a complement-driven neurodegenerative cascade.
Journal ArticleDOI
Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease.
TL;DR: The increase in APP-751/APP-695 mRNA provides a molecular marker for regional variations in plaque density between individuals diagnosed with Alzheimer's disease by the commonly used composite criteria.