G
Giulio Maria Pasinetti
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 348
Citations - 23545
Giulio Maria Pasinetti is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Alzheimer's disease & Hippocampal formation. The author has an hindex of 75, co-authored 331 publications receiving 21345 citations. Previous affiliations of Giulio Maria Pasinetti include University of Brescia & Mount Sinai Health System.
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Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
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Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease
Lap Ho,Weiping Qin,Patrick Pompl,Zhongmin Xiang,Jun Wang,Zhong Zhao,Yuanzhen Peng,Gina Cambareri,Anne B. Rocher,Charles V. Mobbs,Patrick R. Hof,Giulio Maria Pasinetti +11 more
TL;DR: It is found that diet‐induced insulin resistance promoted amyloidogenic β‐amyloid (Aβ) A β1–40 and Aβ1–42 peptide generation in the brain that corresponded with increased γ‐secretase activities and decreased insulin degrading enzyme (IDE) activities.
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Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
Weiping Qin,Tianle Yang,Lap Ho,Lap Ho,Zhong Zhao,Jun Wang,Linghong Chen,Wei Zhao,Meenakshisundaram Thiyagarajan,Donal MacGrogan,Joseph T. Rodgers,Pere Puigserver,Junichi Sadoshima,Haiteng Deng,Steven Pedrini,Sam Gandy,Anthony A. Sauve,Giulio Maria Pasinetti,Giulio Maria Pasinetti +18 more
TL;DR: The predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in mouse neurons in vitro by manipulating cellular SIRT1 expression/activity through mechanisms involving the regulation of the serine/threonine Rho kinase ROCK1.
Journal ArticleDOI
Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
TL;DR: It was found that synthetic beta-amyloid peptides induced cyclooxygenase-2 expression in SH-SY5Y neuroblastoma cells in vitro, suggesting a mechanism for cyclo oxygengen enzyme-2 up-regulation in Alzheimer's disease.
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Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease.
Jun Wang,Lap Ho,Wei Zhao,Kenjiro Ono,Clark Rosensweig,Linghong Chen,Nelson Humala,David B. Teplow,Giulio Maria Pasinetti +8 more
TL;DR: It is found that a naturally derived grape seed polyphenolic extract can significantly inhibit amyloid β-protein aggregation into high-molecular-weight oligomers in vitro and suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD.