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Irm Hermans-Borgmeyer
Researcher at University of Hamburg
Publications - 95
Citations - 8588
Irm Hermans-Borgmeyer is an academic researcher from University of Hamburg. The author has contributed to research in topics: Receptor & SOX10. The author has an hindex of 40, co-authored 86 publications receiving 8042 citations. Previous affiliations of Irm Hermans-Borgmeyer include Salk Institute for Biological Studies.
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SOX10 mutations in patients with Waardenburg-Hirschsprung disease.
Veronique Pingault,Nadege Bondurand,Kirsten Kuhlbrodt,Derk E. Goerich,Marie Odette Préhu,Aldamaria Puliti,Beate Herbarth,Irm Hermans-Borgmeyer,Eric Legius,Gert Matthijs,Jeanne Amiel,Stanislas Lyonnet,Isabella Ceccherini,Giovanni Romeo,Jill Clayton Smith,Andrew P Read,Michael Wegner,Michel Goossens +17 more
TL;DR: It is shown that patients from four families with WS4 have mutations in SOx10, whereas no mutation could be detected in patients with HSCR alone, and this point to an essential role ofSOx10 in the development of two neural crest-derived human cell lineages.
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Sox10, a Novel Transcriptional Modulator in Glial Cells
TL;DR: A role for Sox10 is proposed in conferring cell specificity to the function of other transcription factors in developing and mature glia, including Pax3 and Krox-20, twoother transcription factors involved in Schwann cell development.
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Cloning of a novel glutamate receptor subunit, GluR5 : expression in the nervous system during development
Bernhard Bettler,Jim Boulter,Irm Hermans-Borgmeyer,A O'Shea-Greenfield,Evan S. Deneris,Carl Moll,Uwe Borgmeyer,Michael Hollmann,Stephen F. Heinemann +8 more
TL;DR: The GluR5 protein forms homomeric ion channels in Xenopus oocytes that are weakly responsive to L-glutamate and is detected in areas of neuronal differentiation and synapse formation during embryogenesis.
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Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA.
TL;DR: The cloning and expression of a functional rat glutamate receptor subunit cDNA, GluR6, which has a very different pharmacology from that of the GluLl–GluR4 class and exhibits an outwardly rectifying current–voltage relationship.
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Disruption of KCC2 Reveals an Essential Role of K-Cl Cotransport Already in Early Synaptic Inhibition
Christian A. Hübner,Valentin Stein,Irm Hermans-Borgmeyer,Torsten Meyer,Klaus Ballanyi,Thomas J. Jentsch +5 more
TL;DR: It is shown that KCC2 knockout mice died immediately after birth due to severe motor deficits that also abolished respiration and Sciatic nerve recordings revealed abnormal spontaneous electrical activity and altered spinal cord responses to peripheral electrical stimuli.