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Isaac J. Hayward
Researcher at Amgen
Publications - 2
Citations - 640
Isaac J. Hayward is an academic researcher from Amgen. The author has contributed to research in topics: Neovascularization & Angiogenesis. The author has an hindex of 2, co-authored 2 publications receiving 619 citations.
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Journal ArticleDOI
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
Jonathan D. Oliner,Hosung Min,Juan Leal,Dongyin Yu,Shashirekha Rao,Edward You,Xiu Tang,Haejin Kim,Susanne Meyer,Seog Joon Han,Nessa Hawkins,Robert Rosenfeld,E. Davy,Kevin Graham,Frederick W. Jacobsen,Shirley Stevenson,Joanne Ho,Qing Chen,Thomas Hartmann,Mark Leo Michaels,Michael J. Kelley,Luke Li,Karen C. Sitney,Frank Martin,Ji-Rong Sun,Nancy Zhang,John Lu,Juan Estrada,Rakesh Kumar,Angela Coxon,Stephen Kaufman,James Pretorius,Sheila Scully,Russ Cattley,Marc Payton,Steve Coats,Linh Nguyen,Binodh DeSilva,Anthony Ndifor,Isaac J. Hayward,Robert Radinsky,Tom Boone,Richard Kendall +42 more
TL;DR: In this paper, the authors showed that specific Ang2 inhibition may represent an effective anti-angiogenic strategy for treating patients with solid tumors, and they showed that anti-Ang2 therapy also prevented VEGF-stimulated neovascularization in a rat corneal model of angiogenesis.
Journal ArticleDOI
Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody
Angela Coxon,James Bready,Hosung Min,Stephen J. Kaufman,Juan Leal,Dongyin Yu,Tani Ann Lee,Ji-Rong Sun,Juan Estrada,Brad Bolon,James M. McCabe,Ling Wang,Karen Rex,Sean Caenepeel,Paul E. Hughes,David Cordover,Haejin Kim,Seog Joon Han,Mark Leo Michaels,Eric Hsu,Grant Shimamoto,Russell C. Cattley,Eunju Hurh,Linh T. Nguyen,Shao Xiong Wang,Anthony Ndifor,Isaac J. Hayward,Beverly L. Falcón,Donald M. McDonald,Luke Li,Tom Boone,Richard Kendall,Robert Radinsky,Jonathan D. Oliner +33 more
TL;DR: Results imply that Ang1 plays a context-dependent role in promoting postnatal angiogenesis and that dual Ang1/2 inhibition is superior to selective Ang2 inhibition for suppression ofAngiogenesis in some postnatal settings.