F
Frederick W. Jacobsen
Researcher at Amgen
Publications - 47
Citations - 5101
Frederick W. Jacobsen is an academic researcher from Amgen. The author has contributed to research in topics: Nucleic acid & Antibody. The author has an hindex of 17, co-authored 47 publications receiving 4934 citations.
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Journal ArticleDOI
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
Krisztina M. Zsebo,David A. Williams,Edwin N. Geissler,Virginia C. Broudy,Francis Hall Martin,Harry L. Atkins,Rou Yin Hsu,Neal C. Birkett,Kenneth H. Okino,Murdock Douglas C,Frederick W. Jacobsen,Keith Langley,Kent A. Smith,Takashi Takeish,Bruce M. Cattanach,Stephen J. Galli,Sidney Vaughn Suggs +16 more
TL;DR: In vivo administration of SCF can reverse the macrocytic anemia and locally repair the mast cell deficiency of Sl/Sld mice and provide biological and physical evidence that SCF is a ligand for the c-kit receptor.
Journal ArticleDOI
Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI
T.D. Bartley,Jakob M. Bogenberger,P Hunt,Yang Li,Hsieng Sen Lu,Francis Hall Martin,Ming-Shi Chang,Babru B Samal,J.L. Nichol,S. Swift,Merrie J. Johnson,R.-Y. Hsu,Vann P. Parker,Sidney Vaughn Suggs,J.D. Skrine,L.A. Merewether,C. Clogston,E. Hsu,M.M. Hokom,A. Hornkohl,E. Choi,M. Pangelinan,Y. Sun,V L Mar,Jennifer McNinch,L. Simonet,Frederick W. Jacobsen,C. Xie,John R. Shutter,H. Chute,Rita Basu,L. Selander,D. Trollinger,L. Sieu,D. Padilla,Geraldine Trail,G. Elliott,R. Izumi,T. Covey,J. Crouse,A. Garcia,W. Xu,J. Del Castillo,J. Biron,S. Cole,Mickey C.T. Hu,R. Pacifici,I. Ponting,Chris Saris,Duanzhi Wen,Y.P. Yung,H. Lin,R.A. Rosselman +52 more
TL;DR: MGDF is a novel cytokine that regulates megakaryocyte development and is a ligand for the MPI receptor, and its biological activities are blocked by the soluble extracellular domain of MpI.
Journal ArticleDOI
Primary structure and functional expression of rat and human stem cell factor DNAs
Francis Hall Martin,Sidney Vaughn Suggs,Keith Langley,Hsieng Sen Lu,Jerry Ting,Kenneth H. Okino,C. Fred Morris,Ian K. McNiece,Frederick W. Jacobsen,Elizabeth A. Mendlaz,Neal C. Birkett,Kent A. Smith,Merrie J. Johnson,Vann P. Parker,Josephine C. Flores,Avantika C. Patel,Eric F. Fisher,Holly O. Erjavec,Charles J. Herrera,Jette Wypych,Raj Kumar Sachdev,Joseph A. Pope,Ian Leslie,Duanzhi Wen,Chi Hwei Lin,Rod Cupples,Krisztina M. Zsebo +26 more
TL;DR: Using probes based on the rat sequence, partial and full-length cDNA and genomic clones of human SCF have been isolated and exhibit potent synergistic activities in conjunction with colony-stimulating factors, resulting in increased colony numbers and colony size.
Journal ArticleDOI
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
Jonathan D. Oliner,Hosung Min,Juan Leal,Dongyin Yu,Shashirekha Rao,Edward You,Xiu Tang,Haejin Kim,Susanne Meyer,Seog Joon Han,Nessa Hawkins,Robert Rosenfeld,E. Davy,Kevin Graham,Frederick W. Jacobsen,Shirley Stevenson,Joanne Ho,Qing Chen,Thomas Hartmann,Mark Leo Michaels,Michael J. Kelley,Luke Li,Karen C. Sitney,Frank Martin,Ji-Rong Sun,Nancy Zhang,John Lu,Juan Estrada,Rakesh Kumar,Angela Coxon,Stephen Kaufman,James Pretorius,Sheila Scully,Russ Cattley,Marc Payton,Steve Coats,Linh Nguyen,Binodh DeSilva,Anthony Ndifor,Isaac J. Hayward,Robert Radinsky,Tom Boone,Richard Kendall +42 more
TL;DR: In this paper, the authors showed that specific Ang2 inhibition may represent an effective anti-angiogenic strategy for treating patients with solid tumors, and they showed that anti-Ang2 therapy also prevented VEGF-stimulated neovascularization in a rat corneal model of angiogenesis.
Journal ArticleDOI
Germline transmission of exogenous genes in the chicken
Robert A. Bosselman,Rou-Yin Hsu,T. Boggs,Sylvia Hu,Joan Bruszewski,Susan Ou,Lee Kozar,Frank Martin,Cal Green,Frederick W. Jacobsen,Margery O. Nicolson,Joseph A. Schultz,Kenneth M. Semon,William Rishell,R. Gregory Stewart +14 more
TL;DR: Primordial germ cells present in the unincubated chicken embryo blastoderm are susceptible to infection by defective REV vectors.