J
Ji-Rong Sun
Researcher at Amgen
Publications - 8
Citations - 740
Ji-Rong Sun is an academic researcher from Amgen. The author has contributed to research in topics: Angiogenesis & Cell growth. The author has an hindex of 6, co-authored 8 publications receiving 700 citations.
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Journal ArticleDOI
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2.
Jonathan D. Oliner,Hosung Min,Juan Leal,Dongyin Yu,Shashirekha Rao,Edward You,Xiu Tang,Haejin Kim,Susanne Meyer,Seog Joon Han,Nessa Hawkins,Robert Rosenfeld,E. Davy,Kevin Graham,Frederick W. Jacobsen,Shirley Stevenson,Joanne Ho,Qing Chen,Thomas Hartmann,Mark Leo Michaels,Michael J. Kelley,Luke Li,Karen C. Sitney,Frank Martin,Ji-Rong Sun,Nancy Zhang,John Lu,Juan Estrada,Rakesh Kumar,Angela Coxon,Stephen Kaufman,James Pretorius,Sheila Scully,Russ Cattley,Marc Payton,Steve Coats,Linh Nguyen,Binodh DeSilva,Anthony Ndifor,Isaac J. Hayward,Robert Radinsky,Tom Boone,Richard Kendall +42 more
TL;DR: In this paper, the authors showed that specific Ang2 inhibition may represent an effective anti-angiogenic strategy for treating patients with solid tumors, and they showed that anti-Ang2 therapy also prevented VEGF-stimulated neovascularization in a rat corneal model of angiogenesis.
Journal ArticleDOI
Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing Peptibody
Angela Coxon,James Bready,Hosung Min,Stephen J. Kaufman,Juan Leal,Dongyin Yu,Tani Ann Lee,Ji-Rong Sun,Juan Estrada,Brad Bolon,James M. McCabe,Ling Wang,Karen Rex,Sean Caenepeel,Paul E. Hughes,David Cordover,Haejin Kim,Seog Joon Han,Mark Leo Michaels,Eric Hsu,Grant Shimamoto,Russell C. Cattley,Eunju Hurh,Linh T. Nguyen,Shao Xiong Wang,Anthony Ndifor,Isaac J. Hayward,Beverly L. Falcón,Donald M. McDonald,Luke Li,Tom Boone,Richard Kendall,Robert Radinsky,Jonathan D. Oliner +33 more
TL;DR: Results imply that Ang1 plays a context-dependent role in promoting postnatal angiogenesis and that dual Ang1/2 inhibition is superior to selective Ang2 inhibition for suppression ofAngiogenesis in some postnatal settings.
Journal ArticleDOI
Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.
Victor J. Cee,Laurie B. Schenkel,Brian L. Hodous,Holly L. Deak,Hanh Nho Nguyen,Philip R. Olivieri,Karina Romero,Annette Bak,Xuhai Be,Steve Bellon,Tammy L. Bush,Alan C. Cheng,Grace Tin-Yun Chung,Steve Coats,Patrick Eden,Kelly Hanestad,Paul Gallant,Yan Gu,Xin Huang,Richard Kendall,Min-Hwa Jasmine Lin,Michael Morrison,Vinod F. Patel,Robert Radinsky,Paul E. Rose,Sandra Ross,Ji-Rong Sun,Jin Tang,Huilin Zhao,Marc Payton,Stephanie D. Geuns-Meyer +30 more
TL;DR: A high-throughput screening effort identified pyridinyl-pyrimidine 6a as a moderately potent dual inhibitor of aurora kinases -A and -B as well as an anthranilamide lead (6j) that possessed improved enzyme and cellular activity and exhibited a high level of kinase selectivity but suffered from a lack of oral bioavailability.
Journal ArticleDOI
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.
John L. Buchanan,John Newcomb,David P. Carney,Stuart C. Chaffee,Lilly Chai,Rod Cupples,Linda F. Epstein,Paul Gallant,Yan Gu,Jean-Christophe Harmange,Kathy Hodge,Brett E. Houk,Xin Huang,Janan Jona,Smriti Joseph,H. Toni Jun,Rakesh Kumar,Chun Li,John Lu,Tom Menges,Michael Morrison,Perry M. Novak,Simon Van Der Plas,Robert Radinsky,Paul E. Rose,Satin Sawant,Ji-Rong Sun,Sekhar Surapaneni,Susan M. Turci,Keyang Xu,Evelyn Yanez,Huilin Zhao,Xiaotian Zhu +32 more
TL;DR: The synthesis, structure-activity relationships (SAR), X-ray cocrystal structure and in vivo tumor study results for a series of 2,4-bis-arylamino-1,3-pyrimidines are reported.
Journal Article
Suppression of angiogenesis and tumor growth by selective inhibition of Angiopoietin-2
Jonathan D. Oliner,Hosung Min,Juan Leal,Dongyin Yu,Shashirekha Rao,Edward You,Xiu Tang,Haejin Kim,Susanne Meyer,Seong Joon Han,Nessa Hawkins,Robert Rosenfeld,E. Davy,Kevin Graham,Frederick W. Jacobsen,Shirley Steavenson,Joanne Ho,Qing Chen,Thomas Hartmann,Mark Leo Michaels,Michael J. Kelley,Luke Li,Karen C. Sitney,Frank Martin,Ji-Rong Sun +24 more
TL;DR: Anti-Ang2 therapy prevented VEGF-stimulated neovascularization in a rat corneal model of angiogenesis and implies that specific Ang2 inhibition may represent an effective antiangiogenic strategy for treating patients with solid tumors.