Karen C. Sitney

TL;DR: It is shown that both wild type and mutant α-synuclein form insoluble fibrillar aggregates with antiparallel β-sheet structure upon incubation at physiological temperature in vitro, and that aggregate formation is accelerated by both PD-linked mutations.

TL;DR: The crystal structure of erythropoietin complexed to the extracellular ligand-binding domains of the erymorphic receptor, determined at 1.9 Å from two crystal forms, shows that erythrooiet in imposes a unique 120° angular relationship and orientation that is responsible for optimal signalling through intracellular kinase pathways.

TL;DR: In this paper, the authors showed that specific Ang2 inhibition may represent an effective anti-angiogenic strategy for treating patients with solid tumors, and they showed that anti-Ang2 therapy also prevented VEGF-stimulated neovascularization in a rat corneal model of angiogenesis.

TL;DR: In this paper, a process for preparing a pharmacologically active compound, in which at least one internal conjugation site of an Fc domain sequence is selected that is amenable to conjugations of an additional functional moiety by a defined conjugational chemistry through the side chain of an amino acid residue at the conjugative site, is described.

TL;DR: In this paper, a hyperglycosylated analog of erythropoietin was proposed for increasing and maintaining hematocrit in a mammal comprising administering a hyper-glycoslyated analog.