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Isabel Matias
Researcher at National Research Council
Publications - 40
Citations - 6643
Isabel Matias is an academic researcher from National Research Council. The author has contributed to research in topics: Endocannabinoid system & Cannabinoid receptor. The author has an hindex of 33, co-authored 38 publications receiving 6257 citations. Previous affiliations of Isabel Matias include Olivetti & Centre national de la recherche scientifique.
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Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
Tiziana Bisogno,Fiona V. Howell,Gareth Williams,Alberto Minassi,Maria Grazia Cascio,Alessia Ligresti,Isabel Matias,Aniello Schiano-Moriello,Praveen Paul,Emma-Jane Williams,Uma Gangadharan,Carl Hobbs,Vincenzo Di Marzo,Patrick Doherty +13 more
TL;DR: The cloning and enzymatic characterization of the first specific sn-1 DAG lipases are reported, providing a possible explanation for a fundamental change in endocannabinoid function during brain development.
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Endocannabinoid control of food intake and energy balance
Vincenzo Di Marzo,Isabel Matias +1 more
TL;DR: The multifaceted regulation of energy homeostasis by endocannabinoids is discussed, together with its applications to the treatment of eating disorders and metabolic syndromes.
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Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia.
Isabel Matias,Marie-Paule Gonthier,Pierangelo Orlando,Vassilis Martiadis,Luciano De Petrocellis,Cristina Cervino,Stefania Petrosino,Laurence Hoareau,Franck Festy,Renato Pasquali,Régis Roche,Mario Maj,Uberto Pagotto,Palmiero Monteleone,Vincenzo Di Marzo +14 more
TL;DR: Peripheral endocannabinoid overactivity might explain why CB(1) blockers cause weight-loss independent reduction of lipogenesis, of hypoadiponectinemia, and of hyperinsulinemia in obese animals and humans.
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Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
Alessia Ligresti,Aniello Schiano Moriello,Katarzyna Starowicz,Isabel Matias,Simona Pisanti,Luciano De Petrocellis,Chiara Laezza,Giuseppe Portella,Maurizio Bifulco,Vincenzo Di Marzo +9 more
TL;DR: Results obtained in a panel of tumor cell lines clearly indicate that, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth, with significantly lower potency in noncancer cells.
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Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men.
Mélanie Côté,Isabel Matias,Isabelle Lemieux,Stefania Petrosino,Natalie Alméras,Jean-Pierre Després,V. Di Marzo +6 more
TL;DR: Evidence is provided for a relationship in men between a key endocannabinoid, 2-AG, and cardiometabolic risk factors, including IAA, which was shown to reduce complications of type 2 diabetes and cardiovascular disease.