Simona Pisanti

TL;DR: Results obtained in a panel of tumor cell lines clearly indicate that, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth, with significantly lower potency in noncancer cells.

TL;DR: The pharmacology of the statins is reviewed, providing a comprehensive update of the current knowledge of their effects on tissues, biological processes, and pathological conditions, and the disappointing evidence on the possible future use of statin-based drugs in cancer therapy is dissected.

TL;DR: This review highlights the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function, and the therapeutic potential of cannabidiol.

TL;DR: It is proposed thatCB1 receptor agonists inhibit tumor cell invasion and metastasis by modulating FAK phosphorylation, and that CB1 receptor activation might represent a novel therapeutic strategy to slow down the growth of breast carcinoma and to inhibit its metastatic diffusion in vivo.

TL;DR: The main signaling pathways for the antitumor effects of the endocannabinoid system in cancer and its basic role in cancer pathogenesis are highlighted, and the alternative view of cannabinoid receptors as tumor promoters is discussed.