G
Gareth Williams
Researcher at Wolfson Centre for Age-Related Diseases
Publications - 96
Citations - 5031
Gareth Williams is an academic researcher from Wolfson Centre for Age-Related Diseases. The author has contributed to research in topics: Neurogenesis & Subventricular zone. The author has an hindex of 34, co-authored 94 publications receiving 4338 citations. Previous affiliations of Gareth Williams include King's College London.
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Journal ArticleDOI
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
Tiziana Bisogno,Fiona V. Howell,Gareth Williams,Alberto Minassi,Maria Grazia Cascio,Alessia Ligresti,Isabel Matias,Aniello Schiano-Moriello,Praveen Paul,Emma-Jane Williams,Uma Gangadharan,Carl Hobbs,Vincenzo Di Marzo,Patrick Doherty +13 more
TL;DR: The cloning and enzymatic characterization of the first specific sn-1 DAG lipases are reported, providing a possible explanation for a fundamental change in endocannabinoid function during brain development.
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Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice
Ying Gao,Dmitry V. Vasilyev,Maria Beatriz De Castro Vasconcelos Goncalves,Fiona V. Howell,Carl Hobbs,Melina Reisenberg,Ru Shen,Mei-Yi Zhang,Brian W. Strassle,Peimin Lu,Lilly Mark,Michael J. Piesla,Kangwen Deng,Evguenia V. Kouranova,Robert H. Ring,Garth T. Whiteside,Brian Bates,Frank S. Walsh,Gareth Williams,Menelas N. Pangalos,Tarek A. Samad,Patrick Doherty +21 more
TL;DR: These findings provide the first evidence that DAGLα is the major biosynthetic enzyme for 2-AG in the nervous system and reveal an essential role for this enzyme in regulating retrograde synaptic plasticity and adult neurogenesis.
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CAMs and axonal growth: a critical evaluation of the role of calcium and the MAPK cascade.
TL;DR: The recent data are considered and it is suggested that calcium and the MAPK cascade might be required for very distinct growth cone functions.
Journal ArticleDOI
A Novel Family of Cyclic Peptide Antagonists Suggests That N-cadherin Specificity Is Determined by Amino Acids That Flank the HAV Motif
TL;DR: It is demonstrated that subtle changes in the amino acids that flank the HAV motif can account for cadherin specificity and that small cyclic peptides can inhibit Cadherin function.
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A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner
Maria B. Goncalves,Philipp Suetterlin,Ping K. Yip,Francisco Molina-Holgado,Deborah J. Walker,Madeleine J. Oudin,Marc P. Zentar,Steven M. Pollard,Rafael J. Yáñez-Muñoz,Gareth Williams,Frank S. Walsh,Menelas N. Pangalos,Patrick Doherty +12 more
TL;DR: These data identify CB2 receptor agonists and FAAH inhibitors as agents that can counteract the naturally observed decline in adult neurogenesis that is associated with ageing.