F
Fiona V. Howell
Researcher at Wolfson Centre for Age-Related Diseases
Publications - 8
Citations - 1723
Fiona V. Howell is an academic researcher from Wolfson Centre for Age-Related Diseases. The author has contributed to research in topics: Diacylglycerol lipase & Endocannabinoid system. The author has an hindex of 5, co-authored 8 publications receiving 1592 citations. Previous affiliations of Fiona V. Howell include King's College London.
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Journal ArticleDOI
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
Tiziana Bisogno,Fiona V. Howell,Gareth Williams,Alberto Minassi,Maria Grazia Cascio,Alessia Ligresti,Isabel Matias,Aniello Schiano-Moriello,Praveen Paul,Emma-Jane Williams,Uma Gangadharan,Carl Hobbs,Vincenzo Di Marzo,Patrick Doherty +13 more
TL;DR: The cloning and enzymatic characterization of the first specific sn-1 DAG lipases are reported, providing a possible explanation for a fundamental change in endocannabinoid function during brain development.
Journal ArticleDOI
Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice
Ying Gao,Dmitry V. Vasilyev,Maria Beatriz De Castro Vasconcelos Goncalves,Fiona V. Howell,Carl Hobbs,Melina Reisenberg,Ru Shen,Mei-Yi Zhang,Brian W. Strassle,Peimin Lu,Lilly Mark,Michael J. Piesla,Kangwen Deng,Evguenia V. Kouranova,Robert H. Ring,Garth T. Whiteside,Brian Bates,Frank S. Walsh,Gareth Williams,Menelas N. Pangalos,Tarek A. Samad,Patrick Doherty +21 more
TL;DR: These findings provide the first evidence that DAGLα is the major biosynthetic enzyme for 2-AG in the nervous system and reveal an essential role for this enzyme in regulating retrograde synaptic plasticity and adult neurogenesis.
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Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth.
Emma-Jane Williams,Gareth Williams,Fiona V. Howell,Stephen D. Skaper,Frank S. Walsh,Patrick Doherty +5 more
TL;DR: It is concluded that N-cadherin contains a novel motility motif in extracellular domain 4, and that peptide mimetics of this motif can interact with the FGFR.
Journal ArticleDOI
The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule
TL;DR: Using deletion mutagenesis, it is found that the adhesion molecule/FGFR interaction can withstand the removal of most of any one of the FGFR immunoglobulin-like domains (D1-D3).
Journal ArticleDOI
Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling.
Erik Keimpema,Alán Alpár,Fiona V. Howell,Katarzyna Malenczyk,Katarzyna Malenczyk,Carl Hobbs,Yasmin L. Hurd,Masahiko Watanabe,Kenji Sakimura,Masanobu Kano,Patrick Doherty,Tibor Harkany,Tibor Harkany +12 more
TL;DR: This work shows that cholinergic innervation of CA1 pyramidal cells of the hippocampus is sensitive to the genetic disruption of 2-AG signaling in DAGLα null mice, and suggests that extracellular 2- AG concentrations can be sufficient to activate CB1Rs along discrete spherical boundaries to modulate neuronal responsiveness.