Isabelle Lihrmann

TL;DR: The present study demonstrates that UII, which has long been regarded as a peptide exclusively produced by the urophysis of teleost fish, is actually present in the brain of amphibians and mammals.

TL;DR: A comparison of the primary structures of mouse and rat UII with those of other vertebrate UII reveals that the sequence of the cyclic region of the molecule has been fully conserved, and the N‐terminal flanking domain of prepro‐UII has markedly diverged with only 48% sequence identity between the mouse or rat and the human precursors.

TL;DR: Stage-specific cardiocyte cultures developed to analyze transcriptional control of the rat atrial natriuretic factor gene are used to unravel the presence of different regulatory mechanisms for transcription of the ANF gene during cardiac differentiation and may be useful for studying the regulatory pathways of other genes that undergo switching during cardiac myogenesis.

TL;DR: The discrete localization of PACAP binding sites as well as PAC1‐R and VPAC2‐R mRNAs in neuroepithelia during embryonic life and postnatal development strongly suggests that PACAP, acting through PAC1-R and/or VPAC1‐ R, may play a crucial role in the regulation of neurogenesis in the rat brain.

TL;DR: The characterization of the cDNA clones that encode two distinct somatostatin precursors in the brain of the frog Rana ridibunda indicates that the two somatstatin variants could exert different functions in the frog brain and pituitary, and suggests that distinct genes encoding som atostatin variants may be expressed in thebrain of other tetrapods.