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Isabelle Seif
Researcher at University of Paris-Sud
Publications - 67
Citations - 5701
Isabelle Seif is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: Serotonin & Monoamine oxidase A. The author has an hindex of 33, co-authored 67 publications receiving 5532 citations. Previous affiliations of Isabelle Seif include Curie Institute & Université Paris-Saclay.
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Knockout Corner: Knockout mice for monoamine oxidase A.
Isabelle Seif,Edward De Maeyer +1 more
TL;DR: A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine, providing an animal model of MAOA deficiency in humans.
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Monoamine oxidase B (MAOB)-containing structures in MAOA-deficient transgenic mice
Keiko Ikemoto,Kunio Kitahama,Isabelle Seif,Toshihiro Maeda,Edward De Maeyer,Jean-Louis Valatx +5 more
TL;DR: The present data suggest that serotonin, a preferential substrate for MAOA, can be oxidized by MAOB in MAOA-deficient Tg8 mice, and the localization of MAOB-positive structures are not different between T g8 mutant and normal C3H line.
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Monoaminergic control of vasopressin and VIP expression in the mouse suprachiasmatic nucleus.
Claire-Marie Vacher,P. Frétier,Christophe Créminon,Isabelle Seif,E. De Maeyer,André Calas,Hélène Hardin-Pouzet +6 more
TL;DR: It is indicated that serotonin and noradrenaline stimulate AVP and VIP expression, and could participate in the differentiation of the neurochemical phenotype in the mouse SCN.
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Differential regulation of adenosine A1 and A2A receptors in serotonin transporter and monoamine oxidase A-deficient mice
Rainald Mössner,Dietmar Albert,Antonio M. Persico,Thomas Hennig,D. Bengel,Bettina Holtmann,Angelika Schmitt,Flavio Keller,Rabi Simantov,Dennis L. Murphy,Isabelle Seif,Jürgen Deckert,Jürgen Deckert,K. Peter Lesch +13 more
TL;DR: The adaptive changes of A(1) and A(2A) receptors in 5HTT-deficient mice are likely to represent a compensatory neuroprotective effect mediated by the adenosinergic modulatory system.
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Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine.
Daniel P. Holschneider,Oscar U. Scremin,Oscar U. Scremin,L. Huynh,K. Chen,Isabelle Seif,Jean C. Shih +6 more
TL;DR: The study suggests that the effects on regional cortical blood flow of a lifelong absence of monoamine oxidase A, and the consequent chronic increase in serotonin and norepinephrine, differ from those attributable to acute increases in these neurotransmitters following fenfluramine administration.