Isaiah Norton

TL;DR: It is shown that SRS microscopy could identify hypercellular tumor regions in fresh surgical specimens from a patient with glioblastoma, and a correlation between SRS and hematoxylin and eosin microscopy for detection of glioma infiltration is demonstrated.

TL;DR: Together, the findings offer proof of concept that intraoperative examination and classification of brain tissue by mass spectrometry can provide surgeons, pathologists, and oncologists with critical and previously unavailable information to rapidly guide surgical resections that can improve management of patients with malignant brain tumors.

TL;DR: The work demonstrates that DESI-MS technology has the potential to identify the histology type of brain tumors and provides information on glioma grade and, most importantly, may help define tumor margins by measuring the tumor cell concentration in a specimen.

TL;DR: It is shown that a validated molecular marker—2-hydroxyglutarate generated from isocitrate dehydrogenase 1 mutant gliomas—can be rapidly detected from tumors using a form of ambient MS that does not require sample preparation, indicating that metabolite-imaging MS could transform many aspects of surgical care.

TL;DR: It is shown that tumor margins can be identified using the spatial distributions and varying intensities of different lipids, and an MS-based method could be developed for the rapid intraoperative detection of residual cancer tissue during breast-conserving surgery.