Ian F. Dunn

TL;DR: Observations indicate that TBK1 and NF-κB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer.

TL;DR: Stricker et al. as discussed by the authors performed whole-exome sequencing of 86 matched brain metastases, primary tumors, and normal tissue and found potentially clinically informative alterations in the brain metastasis not detected in the matched primary-tumor sample.

TL;DR: The authors review the current state of AI as applied to medical imaging of cancer and describe advances in 4 tumor types to illustrate how common clinical problems are being addressed.

TL;DR: It is shown that the suppression of CDK8 expression inhibits proliferation in colon cancer cells characterized by high levels ofCDK8 and β-catenin hyperactivity, suggesting that therapeutic interventions targeting CDK 8 may confer a clinical benefit in β-Catenin-driven malignancies.

TL;DR: It is shown that activation of the ERK and phosphatidylinositol 3-kinase (PI3K) signaling pathways cooperate to transform human cells and suggest a mechanism for NF-kappaB activation in breast cancer, implicate the NF- kappaB pathway as a downstream mediator of PI3K, and provide a framework for integrated genomic approaches in oncogene discovery.