D
David Calligaris
Researcher at Brigham and Women's Hospital
Publications - 36
Citations - 2201
David Calligaris is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Mass spectrometry & MALDI imaging. The author has an hindex of 23, co-authored 35 publications receiving 1757 citations. Previous affiliations of David Calligaris include Harvard University & Aix-Marseille University.
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Journal ArticleDOI
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery
Sandro Santagata,Livia S. Eberlin,Isaiah Norton,David Calligaris,Daniel Feldman,Jennifer L. Ide,Xiaohui Liu,Joshua S. Wiley,Matthew L. Vestal,Shakti Ramkissoon,Daniel A. Orringer,Kristen K. Gill,Ian F. Dunn,Dora Dias-Santagata,Keith L. Ligon,Ferenc A. Jolesz,Alexandra J. Golby,R. Graham Cooks,Nathalie Y. R. Agar +18 more
TL;DR: It is shown that a validated molecular marker—2-hydroxyglutarate generated from isocitrate dehydrogenase 1 mutant gliomas—can be rapidly detected from tumors using a form of ambient MS that does not require sample preparation, indicating that metabolite-imaging MS could transform many aspects of surgical care.
Journal ArticleDOI
Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis
David Calligaris,Diana Caragacianu,Xiaohui Liu,Isaiah Norton,Christopher J. Thompson,Andrea L. Richardson,Andrea L. Richardson,Mehra Golshan,Michael L. Easterling,Sandro Santagata,Sandro Santagata,Deborah A. Dillon,Ferenc A. Jolesz,Nathalie Y. R. Agar +13 more
TL;DR: It is shown that tumor margins can be identified using the spatial distributions and varying intensities of different lipids, and an MS-based method could be developed for the rapid intraoperative detection of residual cancer tissue during breast-conserving surgery.
Journal ArticleDOI
Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents.
Choi-Fong Cho,Choi-Fong Cho,Justin M. Wolfe,Colin M. Fadzen,David Calligaris,Kalvis Hornburg,E. Antonio Chiocca,Nathalie Y. R. Agar,Bradley L. Pentelute,Sean E. Lawler +9 more
TL;DR: It is reported that self-assembling multicellular BBB spheroids display reproducible BBB features and functions, and could serve as a valuable next-generation platform for expediting the development of CNS therapeutics.
Journal ArticleDOI
Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma
Christian Braun,Monica Stanciu,Paul L. Boutz,Jesse C. Patterson,David Calligaris,Fumi Higuchi,Rachit Neupane,Silvia Fenoglio,Daniel P. Cahill,Hiroaki Wakimoto,Nathalie Y. R. Agar,Nathalie Y. R. Agar,Michael B. Yaffe,Michael B. Yaffe,Phillip A. Sharp,Michael T. Hemann,Jacqueline A. Lees +16 more
TL;DR: In this article, the authors identify a biomarker that predicts sensitivity to PRMT5 inhibition in Glioblastoma multiforme (GBM) patients, including patient-derived xenografts.
Journal ArticleDOI
Blocking Lipid Synthesis Overcomes Tumor Regrowth and Metastasis after Antiangiogenic Therapy Withdrawal
Nor Eddine Sounni,Jonathan Cimino,Silvia Blacher,Irina Primac,Alice Truong,Gabriel Mazzucchelli,Alexandra Paye,David Calligaris,Delphine Debois,Pascal De Tullio,Bernard Mari,Edwin De Pauw,Agnès Noël +12 more
TL;DR: Evidence for tumor adaptation to vascular endothelial growth factor blockade through a metabolic shift toward carbohydrate and lipid metabolism in tumors is provided and key molecules involved in lipid metabolism as putative therapeutic targets are identified.