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Isaku Kohama
Researcher at Gunma University
Publications - 10
Citations - 165
Isaku Kohama is an academic researcher from Gunma University. The author has contributed to research in topics: Microvesicles & Sarcoma. The author has an hindex of 4, co-authored 10 publications receiving 101 citations.
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Journal ArticleDOI
Development of miRNA-based therapeutic approaches for cancer patients.
TL;DR: Recent progress in the development of miRNA therapeutics for the treatment of cancer patients is summarized, and delivery systems for oligonucleotide therapeutics are described.
Journal ArticleDOI
Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer
Iwao Shimomura,Akira Yokoi,Isaku Kohama,Minami Kumazaki,Yuji Tada,Koichiro Tatsumi,Takahiro Ochiya,Yusuke Yamamoto +7 more
TL;DR: It is demonstrated that these benzimidazole derivatives play an important role in suppressing KRAS-mutant lung cancer cells, thus offering a novel combinatorial therapeutic approach against such cancer cells.
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An Insight into the Roles of MicroRNAs and Exosomes in Sarcoma.
TL;DR: This review summarizes the studies of miRNA and exosomes in sarcoma and indicates that these miRNAs andExosomes can be targeted as biomarkers and treatments.
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Impact of Carbon Ion Radiotherapy on Inoperable Bone Sarcoma.
Shintaro Shiba,Masahiko Okamoto,Hiroki Kiyohara,Shohei Okazaki,Takuya Kaminuma,Kei Shibuya,Isaku Kohama,Kenichi Saito,Takashi Yanagawa,Hirotaka Chikuda,Takashi Nakano,Tatsuya Ohno +11 more
TL;DR: In this paper, the clinical outcomes of patients with bone sarcoma who were treated with carbon ion radiotherapy (C-ion RT) have been analyzed for 3-year overall survival, local control (LC), and progression-free survival (PFS) rates.
Journal ArticleDOI
Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma
Isaku Kohama,Naofumi Asano,Juntaro Matsuzaki,Yusuke Yamamoto,Tomofumi Yamamoto,Ryou-u Takahashi,Eisuke Kobayashi,Satoko Takizawa,Hiromi Sakamoto,Ken Kato,Hiroyuki Fujimoto,Hirotaka Chikuda,Akira Kawai,Takahiro Ochiya +13 more
TL;DR: The role of miRNAs and exosomes in the pathogenesis of sarcoma remains unclear as mentioned in this paper, however, the role of exosome and miR-1246, -4532, -4454, -619-5p and -6126 as biomarkers for dedifferentiated liposarcoma was identified.