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Issaka Yougbaré
Researcher at St. Michael's Hospital
Publications - 28
Citations - 1093
Issaka Yougbaré is an academic researcher from St. Michael's Hospital. The author has contributed to research in topics: Neonatal alloimmune thrombocytopenia & Systemic lupus erythematosus. The author has an hindex of 15, co-authored 28 publications receiving 890 citations. Previous affiliations of Issaka Yougbaré include Université de Sherbrooke & Sanofi Pasteur.
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Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
June Li,Dianne E. van der Wal,Guangheng Zhu,Miao Xu,Issaka Yougbaré,Li Ma,Brian Vadasz,Naadiya Carrim,Renata Grozovsky,Min Ruan,Lingyan Zhu,Qingshu Zeng,Lili Tao,Zhimin Zhai,Jun Peng,Ming Hou,Valery Leytin,John Freedman,Karin M. Hoffmeister,Heyu Ni +19 more
TL;DR: Light is shed on Fc-independent cytopenias, designating desialylation as a potential diagnostic biomarker and therapeutic target in the treatment of refractory ITP.
Journal ArticleDOI
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
Conglei Li,June Li,Yan-Yan Li,Yan-Yan Li,Sean Lang,Sean Lang,Issaka Yougbaré,Guangheng Zhu,Pingguo Chen,Pingguo Chen,Heyu Ni +10 more
TL;DR: New data suggest that platelets are important immune cells and may contribute to innate and adaptive immunity under both physiological and pathological conditions.
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Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.
TL;DR: Curcumin exerts its anti-cancer property by targeting PDE1 that inhibits melanoma cell proliferation via UHRF1, DNMT1, cyclin A, p21 and p27 regulations, which suggests that natural Pde1 inhibitors present in food might be effective in preventing cancer.
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Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage
Issaka Yougbaré,Sean Lang,Hong Yang,Pingguo Chen,Xu Zhao,Wei-She Tai,Darko Zdravic,Brian Vadasz,Conglei Li,Siavash Piran,Alexandra H. Marshall,Guangheng Zhu,Heidi Tiller,Mette Kjaer Killie,Shelley R. Boyd,Howard Leong-Poi,Xiao-Yan Wen,Bjørn Skogen,S. Lee Adamson,John Freedman,Heyu Ni +20 more
TL;DR: The data suggest that fetal hemostasis is distinct and that impairment of angiogenesis rather than thrombocytopenia likely causes FNAIT-associated ICH, and indicates that maternal IVIG therapy can effectively prevent this devastating disorder.
Journal ArticleDOI
Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia
Issaka Yougbaré,Issaka Yougbaré,Wei-She Tai,Darko Zdravic,Brigitta Elaine Oswald,Sean Lang,Guangheng Zhu,Howard Leong-Poi,Dawei Qu,Lisa Yu,Caroline Dunk,Jianhong Zhang,John G. Sled,John G. Sled,Stephen J. Lye,Stephen J. Lye,Jelena Brkić,Chun Peng,Petter Höglund,B. Anne Croy,S. Lee Adamson,S. Lee Adamson,Xiao-Yan Wen,Xiao-Yan Wen,Duncan J. Stewart,John Freedman,Heyu Ni +26 more
TL;DR: It is shown that uterine natural killer cell-mediated trophoblast apoptosis contributes to FNAIT pathogenesis, and it is suggested that anti-NK cell therapies may prevent immune-mediated pregnancy loss and ameliorate FNAit.