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Istvan Jona
Researcher at University of Debrecen
Publications - 51
Citations - 2009
Istvan Jona is an academic researcher from University of Debrecen. The author has contributed to research in topics: Ryanodine receptor & Calcium. The author has an hindex of 22, co-authored 51 publications receiving 1934 citations. Previous affiliations of Istvan Jona include State University of New York System & Hungarian Academy of Sciences.
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Journal ArticleDOI
Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification
Xavier Altafaj,János Almássy,Istvan Jona,Daniela Rossi,Vincenzo Sorrentino,Kamel Mabrouk,Michel De Waard,Michel Ronjat +7 more
TL;DR: Functional studies show that, in contrast with what is observed with RyR1, MCa does not affect the gating properties of RyR2, and this results highlight a different role of the MCa-binding domains in the gates process ofRyR1 andRyR2.
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Regulation of the rat sarcoplasmic reticulum calcium release channel by calcium.
TL;DR: The regulation by calcium of the ryanodine receptor/SR calcium release channel from rat skeletal muscle was studied under isolated conditions and in situ and the data are in agreement with a model where calcium binding to the inhibitory site on RyR would be responsible for the calcium dependent inactivation in situ.
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Bile acids activate ryanodine receptors in pancreatic acinar cells via a direct allosteric mechanism.
TL;DR: The results strongly suggest that TCA opens RyR by an allosteric mechanism, which contribute significantly to bile acid-induced pathologic Ca(2+)-leak from the endoplasmic reticulum in pancreatic acinar cells.
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Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities
Attila Sipos,Gábor Máté,Erzsébet Rőth,Anikó Borbás,Gyula Batta,Ilona Bereczki,Sándor Kéki,Istvan Jona,Eszter Ostorházi,Ferenc Rozgonyi,Evelien Vanderlinden,Lieve Naesens,Pál Herczegh +12 more
TL;DR: The new compounds exhibited potent antibacterial and anti-influenza virus activity and the cluster forming and fluorescent properties of the aglycon derivatives were also studied.
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The effect of high pressure on the conformation, interactions and activity of the Ca2+-ATPase of sarcoplasmic reticulum
Istvan Jona,Anthony Martonosi +1 more
TL;DR: It is suggested that high pressure stabilized the enzyme in an E2-like state characterized by low reactivity with ATP and Ca2+ and high reactions with Pi, which is relatively insensitive to high pressure.