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Italo Faria do Valle
Researcher at Northeastern University
Publications - 38
Citations - 1087
Italo Faria do Valle is an academic researcher from Northeastern University. The author has contributed to research in topics: Network medicine & Medicine. The author has an hindex of 13, co-authored 31 publications receiving 598 citations. Previous affiliations of Italo Faria do Valle include Coordenadoria de Aperfeiçoamento de Pessoal de Nível Superior & Universidade Federal de Minas Gerais.
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Network Medicine Framework for Identifying Drug Repurposing Opportunities for COVID-19
Deisy Morselli Gysi,Italo Faria do Valle,Marinka Zitnik,Asher Ameli,Xiao Gan,Onur Varol,Susan Dina Ghiassian,J. J. Patten,Robert A. Davey,Joseph Loscalzo,Albert-László Barabási +10 more
TL;DR: Three network-based drug repurposing strategies are deployed, relying on network proximity, diffusion, and AI-based metrics, allowing to rank all approved drugs based on their likely efficacy for COVID-19 patients, and aggregate all predictions, to arrive at 81 promising repurpose candidates.
Journal ArticleDOI
Network medicine framework for identifying drug-repurposing opportunities for COVID-19.
Deisy Morselli Gysi,Deisy Morselli Gysi,Italo Faria do Valle,Marinka Zitnik,Asher Ameli,Xiao Gan,Xiao Gan,Onur Varol,Helia N. Sanchez,Rebecca M. Baron,Dina Ghiassian,Joseph Loscalzo,Albert-László Barabási,Albert-László Barabási,Albert-László Barabási +14 more
TL;DR: In this article, the authors deployed algorithms relying on artificial intelligence, network diffusion, and network proximity, tasking each of them to rank 6,340 drugs for their expected efficacy against SARS-CoV-2.
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Optimized pipeline of MuTect and GATK tools to improve the detection of somatic single nucleotide polymorphisms in whole-exome sequencing data
Italo Faria do Valle,Italo Faria do Valle,Enrico Giampieri,Giorgia Simonetti,Antonella Padella,Marco Manfrini,Anna Maria Ferrari,Cristina Papayannidis,Isabella Zironi,Marianna Garonzi,Simona Bernardi,Massimo Delledonne,Giovanni Martinelli,Daniel Remondini,Gastone Castellani +14 more
TL;DR: A pipeline that detects a wide range of somatic single nucleotide variants, with good validation rates, from exome sequencing data of cancer samples is presented and the advantage of combining standard algorithms to create the GATK-LODN method, that increased specificity and sensitivity of GatK results is shown.
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Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer.
Danielle Fernandes Durso,Danielle Fernandes Durso,Maria Giulia Bacalini,Claudia Sala,Claudia Sala,Chiara Pirazzini,Elena Marasco,Massimiliano Bonafè,Italo Faria do Valle,Davide Gentilini,Gastone Castellani,Gastone Castellani,Ana Maria Caetano Faria,Claudio Franceschi,Paolo Garagnani,Christine Nardini +15 more
TL;DR: It is shown that the epigenetic age estimated from blood DNA methylation data is statistically significantly associated to future breast and male colorectal cancer development, suggesting that the chance of developing age-related diseases may be predicted by circulating epigenetic markers, with a dependence upon tumor type, sex and age estimator.
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RUNX2 expression in thyroid and breast cancer requires the cooperation of three non-redundant enhancers under the control of BRD4 and c-JUN.
Valentina Sancisi,Gloria Manzotti,Mila Gugnoni,Teresa Rossi,Greta Gandolfi,Giulia Gobbi,Federica Torricelli,Francesca Catellani,Italo Faria do Valle,Daniel Remondini,Gastone Castellani,Moira Ragazzi,Simonetta Piana,Alessia Ciarrocchi +13 more
TL;DR: This work showed that RUNX2 transcription in thyroid and breast cancer requires the cooperation of three distantly located enhancers (ENHs) brought together by chromatin three-dimensional looping and identified c-JUN as the principal pivot of this regulatory platform.