Christine Nardini

TL;DR: This work combined neuroimaging and DNA microarray analysis to create a multidimensional map of gene-expression patterns in GBM that provided clinically relevant insights into tumor biology and provided an in vivo portrait of genome-wide gene expression.

TL;DR: The impact of age-associated factors such as inflammaging, immunosenescence and immunobiography on immune response to vaccination in the elderly is analyzed, and systems biology approaches are considered as a mean for integrating a multitude of data in order to rationally design vaccination approaches specifically tailored for the elderly.

TL;DR: A simple and computationally efficient imputation method, metyhLImp, based on linear regression is presented based on the observation that methylation levels show a high degree of inter-sample correlation and the results of the analysis provide recommendations for accurate estimation of missing methylation values.

TL;DR: TOM, a web-based resource for the efficient extraction of candidate genes for hereditary diseases, allows the geneticist to bypass the costly and time consuming tracing of genetic markers through entire families and might improve the chance of identifying disease genes, particularly for rare diseases.

TL;DR: It is shown that the epigenetic age estimated from blood DNA methylation data is statistically significantly associated to future breast and male colorectal cancer development, suggesting that the chance of developing age-related diseases may be predicted by circulating epigenetic markers, with a dependence upon tumor type, sex and age estimator.