Giorgia Simonetti

TL;DR: This review recapitulates and discusses the most recent findings on the biological function of WEE1/PKMYT1 during the cell cycle and in the DNA damage repair, with a focus on their dual role as tumor suppressors in nonmalignant cells and pseudo-oncogenes in cancer cells.

TL;DR: Whether CML LSCs are susceptible to targeting by tyrosine kinase inhibitors (TKIs) and other drugs, and whether elimination of CMLLSCs is needed to achieve therapy-free remission or cure CML is considered.

TL;DR: A pipeline that detects a wide range of somatic single nucleotide variants, with good validation rates, from exome sequencing data of cancer samples is presented and the advantage of combining standard algorithms to create the GATK-LODN method, that increased specificity and sensitivity of GatK results is shown.

TL;DR: The results establish the important role of macrophages in CLL and suggest therapeutic strategies based on interfering with leukemia-macrophage interactions and co-targeting TAMs and CD20-expressing leukemic cells provides a survival benefit in the mice.

TL;DR: It is shown that chromothripsis frequently occurs in AML (6.6%) and influences patient prognosis and disease biology and FISH showed that chromothyrosine is associated with marker, derivative, and ring chromosomes.