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Iván Velasco
Researcher at National Autonomous University of Mexico
Publications - 67
Citations - 4733
Iván Velasco is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Neural stem cell & Embryonic stem cell. The author has an hindex of 21, co-authored 60 publications receiving 4513 citations. Previous affiliations of Iván Velasco include Thomas Jefferson University & Laboratory of Molecular Biology.
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Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease
Jong-Hoon Kim,Jonathan M. Auerbach,José A. Rodríguez-Gómez,Iván Velasco,Denise K. Gavin,Nadya Lumelsky,Sang-Hun Lee,John Bang Nguyen,Rosario Sanchez-Pernaute,Krys S. Bankiewicz,Ronald D.G. McKay +10 more
TL;DR: It is shown that a highly enriched population of midbrain neural stem cells can be derived from mouse ES cells and the dopamine neurons generated by these stem cells show electrophysiological and behavioural properties expected of neurons from the midbrain.
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Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets
Nadya Lumelsky,Olivier Blondel,Olivier Blondel,Pascal Laeng,Iván Velasco,Rea Ravin,Ronald D.G. McKay +6 more
TL;DR: This work generated cells expressing insulin and other pancreatic endocrine hormones from mouse ES cells that self-assemble to form three-dimensional clusters similar in topology to normal pancreatic islets where pancreatic cell types are in close association with neurons.
Journal ArticleDOI
Long-Lasting Regeneration After Ischemia in the Cerebral Cortex
Ronen R. Leker,Frank Soldner,Iván Velasco,Denise K. Gavin,Andreas Androutsellis-Theotokis,Ronald D.G. McKay +5 more
TL;DR: Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome.
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Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease.
José A. Rodríguez-Gómez,Jian Qiang Lu,Iván Velasco,Seth N. Rivera,Sami S. Zoghbi,Jeih-San Liow,John L. Musachio,Frederick T. Chin,Hiroshi Toyama,Jurgen Seidel,Michael V. Green,Panayotis K. Thanos,Panayotis K. Thanos,Masanori Ichise,Victor W. Pike,Robert B. Innis,Ronald D.G. McKay +16 more
TL;DR: After transplantation into an animal model, neurons derived from mouse ES cells survived for over 32 weeks, maintained midbrain markers, and had sustained behavioral effects, suggesting that ES cell‐derived neurons show DA release and reuptake and stimulate appropriate postsynaptic responses for long periods after implantation.
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Histamine induces neural stem cell proliferation and neuronal differentiation by activation of distinct histamine receptors
TL;DR: In this article, the authors studied histamine effects on proliferation, cell death and differentiation of neuroepithelial stem cells from rat cerebral cortex in vitro, and found that histamine increased 3-fold the number of neurons after differentiation, mainly by activation of H1 receptor, and also significantly decreased the glial (astrocytic) cell proportion.