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Andreas Androutsellis-Theotokis
Researcher at Dresden University of Technology
Publications - 55
Citations - 3067
Andreas Androutsellis-Theotokis is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 21, co-authored 55 publications receiving 2875 citations. Previous affiliations of Andreas Androutsellis-Theotokis include Laboratory of Molecular Biology & University of Nottingham.
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Journal ArticleDOI
Notch signalling regulates stem cell numbers in vitro and in vivo.
Andreas Androutsellis-Theotokis,Ronen R. Leker,Frank Soldner,Daniel J. Hoeppner,Rea Ravin,Steve W. Poser,Maria Adele Rueger,Soo-Kyung Bae,Raja Kittappa,Ronald D.G. McKay +9 more
TL;DR: Notch receptor activation induces the expression of the specific target genes hairy and enhancer of split 3 and Sonic hedgehog through rapid activation of cytoplasmic signals, including the serine/threonine kinase Akt, the transcription factor STAT3 and mammalian target of rapamycin, and thereby promotes the survival of neural stem cells.
Journal ArticleDOI
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.
A Soeda,M Park,Dae Hee Lee,Arlan Mintz,Andreas Androutsellis-Theotokis,Ronald D.G. McKay,Johnathan A. Engh,Toru Iwama,Takahiro Kunisada,Amin B. Kassam,Ian F. Pollack,Deric M. Park +11 more
TL;DR: It is shown that hypoxia (1% oxygen) promotes the self-renewal capacity of CD133-positive human glioma-derived cancer stem cells (CSCs) and the activation of HIF-1α to enhance theSelf-Renewal activity of CD 133-positive cells and to inhibit the induction of CSC differentiation.
Journal ArticleDOI
Long-Lasting Regeneration After Ischemia in the Cerebral Cortex
Ronen R. Leker,Frank Soldner,Iván Velasco,Denise K. Gavin,Andreas Androutsellis-Theotokis,Ronald D.G. McKay +5 more
TL;DR: Focal cortical ischemia elicits an ongoing neurogenic response that can be enhanced with fibroblast growth factor 2 leading to improved functional outcome.
Journal ArticleDOI
The mammary microenvironment alters the differentiation repertoire of neural stem cells
Brian W. Booth,David L. Mack,Andreas Androutsellis-Theotokis,Ronald D.G. McKay,Corinne A. Boulanger,Gilbert H. Smith +5 more
TL;DR: The conclusion that tissue-specific signals emanating from the stroma and from the differentiated somatic cells of the mouse mammary gland can redirect the NSCs to produce cellular progeny committed to MEC fates is supported.
Journal ArticleDOI
Targeting neural precursors in the adult brain rescues injured dopamine neurons
Andreas Androutsellis-Theotokis,Maria Adele Rueger,Deric M. Park,Haik Mkhikian,Erica Korb,Steve W. Poser,Stuart Walbridge,Jeeva Munasinghe,Alan P. Koretsky,Russel R. Lonser,Ronald D.G. McKay +10 more
TL;DR: A model of Parkinson's disease was used to show that angiopoietin2 and Dll4 rescue injured dopamine neurons with motor behavioral improvement and that a combination of growth factors with little impact on the vasculature retains the ability to stimulate neural precursors and protect dopamine neurons.